نتایج جستجو برای: hn5

تعداد نتایج: 49  

Journal: :Journal of Nanomaterials 2021

The reports show that rutin has good potentials as an anticancer agent; however, poor bioavailability due to its low aqueous solubility. present study was aimed at preparing and evaluating physicochemical properties well the activities of nanocrystals (RNs). RNs were prepared via ultrasonication method. then physicochemically characterized by conventional techniques. cytotoxic effect free on HN...

Journal: :Cancer research 2001
D W Rusnak K Affleck S G Cockerill C Stubberfield R Harris M Page K J Smith S B Guntrip M C Carter R J Shaw A Jowett J Stables P Topley E R Wood P S Brignola S H Kadwell B R Reep R J Mullin K J Alligood B R Keith R M Crosby D M Murray W B Knight T M Gilmer K Lackey

The type I receptor tyrosine kinases constitute a family of transmembrane proteins involved in various aspects of cell growth and survival and have been implicated in the initiation and progression of several types of human malignancies. The best characterized of these proteins are the epidermal growth factor receptor (EGFR) and ErbB-2 (HER-2/neu). We have developed potent quinazoline and pyrid...

Journal: :The Journal of pharmacology and experimental therapeutics 1999
V A Pollack D M Savage D A Baker K E Tsaparikos D E Sloan J D Moyer E G Barbacci L R Pustilnik T A Smolarek J A Davis M P Vaidya L D Arnold J L Doty K K Iwata M J Morin

Phosphorylation of tyrosine residues on the epidermal growth factor (EGF) receptor (EGFr) is an important early event in signal transduction, leading to cell replication for major human carcinomas. CP-358,774 is a potent and selective inhibitor of the EGFr tyrosine kinase and produces selective inhibition of EGF-mediated tumor cell mitogenesis. To assess the pharmacodynamic aspects of EGFr inhi...

Journal: :Cellular oncology : the official journal of the International Society for Cellular Oncology 2010
Ruodan Xu Gro Klitgaard Povlsen Vladislav Soroka Elisabeth Bock Vladimir Berezin

The epidermal growth factor family of receptor tyrosine kinases (ErbBs) plays essential roles in tumorigenesis and cancer disease progression, and therefore has become an attractive target for structure-based drug design. ErbB receptors are activated by ligand-induced homo- and heterodimerization. Structural studies have revealed that ErbB receptor dimers are stabilized by receptor-receptor int...

Journal: :The Journal of organic chemistry 2002
Vladimir Benin Piotr Kaszynski J George Radziszewski

Kinetic measurements for the degradation of 4-hydroxyphenylpentazole (2a) and its salt 2b-NBu4 in CD3OD and in CD2Cl2 provided a set of activation parameters. The resulting free energies of activation in methanol (DeltaG298 = 19.7 kcal/mol for 2a and DeltaG298 = 20.6 kcal/mol for 2b-NBu4) were compared with previous results for the 4-chloro derivative, 2c, and collectively correlated with resul...

2015
Min Hou Jun-Fan Xie Xiang-Pan Kong Yi Zhang Yu-Feng Shao Can Wang Wen-Ting Ren Guang-Fu Cui Le Xin Yi-Ping Hou Bahman Jabbari

Onabotulinumtoxin A (BoNTA) has been reported to be effective in the therapy for migraines. Acupuncture has been used worldwide for the treatment of migraine attacks. Injection of a small amount of drug at acupuncture points is an innovation as compared to traditional acupuncture. The purpose of this study was to evaluate and compare the effectiveness of fixed (muscle)-site and acupoint-site in...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Daisuke Sano Fumihiko Matsumoto David R Valdecanas Mei Zhao David P Molkentine Yoko Takahashi Ehab Y Hanna Vali Papadimitrakopoulou John Heymach Luka Milas Jeffrey N Myers

PURPOSE We investigated whether vandetanib, an inhibitor of the tyrosine kinase activities of vascular endothelial growth factor receptor-2 (VEGFR-2), epidermal growth factor receptor (EGFR), and rearranged during transfection (RET), could augment the antitumor activity of radiation with or without cisplatin in preclinical in vitro and in vivo models of human head and neck squamous cell carcino...

2015
Narasimha Kumar Karanam Liang-Hao Ding Uma Giri John Heymach Michael D. Story

Distant metastasis (DM) and local-regional recurrence (LR) after radiation and chemo therapy are major cause of treatment failure for patients with head and neck squamous cell carcinoma. However, detailed underlying mechanisms leading to DM and LR in patients are not fully understood yet. MiRNA have been proposed as biomarkers in a variety of biological and medical conditions such as cancer and...

Journal: :International journal of cancer 2008
Peter Andersen Mikkel Wandahl Pedersen Anders Woetmann Mette Villingshøj Marie-Thérése Stockhausen Niels Odum Hans Skovgaard Poulsen

Recently, we reported that epidermal growth factor receptor (EGFR) induce expression of a module of genes known to be inducible by interferons and particularly interferon-gamma. Here we show that the module is tightly regulated by EGFR in the 2 human cancer cell lines that overexpress EGFR, A431 and HN5. The module of genes included the tumor suppressor IRF-1, which was used as a prototypical m...

2015
Narasimha Kumar Karanam Liang-Hao Ding Tae Hyun Hwang Hao Tang Michael D. Story

Distant metastasis (DM) and local-regional recurrence (LR) after radiation and chemo therapy are major cause of treatment failure for patients with head and neck squamous cell carcinoma. However, detailed underlying mechanisms leading to DM and LR in patients are not fully understood yet. MiRNA have been proposed as biomarkers in a variety of biological and medical conditions such as cancer and...

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