Hodgkin/Reed-Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) display unique characteristics that discriminate cHL from other B-cell lymphomas and normal B cells. Therefore, comparative gene expression profiling of Hodgkin and non-Hodgkin B cells could lead to the identification of candidate genes that are critical for the pathogenesis of cHL. We performed microarray analysis of Hodgki...

BACKGROUND AND OBJECTIVES Human Herpes 6 virus (HHV-6) could remain latent and chronic in the host cells after primary infection. HHV-6 genome encodes certain transactivation proteins which may results in development of malignant lymphoma. The association of human herpes six virus (HHV-6) infection and Hodgkin and Non-Hodgkin lymphomas is strongly supported by epidemiological studies. The aim o...

BACKGROUND Epidemiologic similarities between Hodgkin lymphoma in young adults (i.e., between 15 and 44 years old) and multiple sclerosis have led to the suggestion that these diseases may have related etiologies. Previous investigations have not supported this hypothesis, but the negative results could have been caused by methodologic problems. We therefore assessed the risk of developing Hodg...

The incidence of Hodgkin lymphoma has increased among adolescents and young adults in recent decades, but the relevant risk factors in early life are still unknown. A national cohort study was conducted of 3,571,574 individuals born in Sweden in 1973-2008 and followed up for Hodgkin lymphoma incidence through 2009, to examine perinatal and family risk factors for Hodgkin lymphoma in childhood t...

Current therapy for Hodgkin disease has resulted in a 5year survival rate of approximately 90% for individuals with asymptomatic stage I and II disease and nearly a 60% survival rate for those with symptomatic stage IV disease (1 ]. This improvement in survival has created an increase in the number of second malignancies occurring after successful treatment of the original disease, a complicati...

1. Nogová L, Reineke T, Brillant C, et al; German Hodgkin Study Group. Lymphocytepredominant and classical Hodgkin’s lymphoma: a comprehensive analysis from the German Hodgkin Study Group. J Clin Oncol. 2008;26(3):434-439. 2. Savage KJ, Skinnider B, Al-Mansour M, Sehn LH, Gascoyne RD, Connors JM. Treating limited-stage nodular lymphocyte predominant Hodgkin lymphoma similarly to classical Hodgk...

A unique feature of the germinal center B cell-derived Hodgkin and Reed/Sternberg cells of classical Hodgkin lymphoma is their lost B cell phenotype and the aberrant expression of factors of other hematopoietic cell types, including ID2 and NOTCH1. As cellular dedifferentiation and upregulation of ID2 and NOTCH1 are typical consequences of a hypoxic response, we wondered whether hypoxia may imp...

common radiologic features of lymphoma in lung are included: adenopathy, pleural effusion, multiple or solitary masses and diffuse infiltration. we want to present a 28y/o male with pulmonary hodgkin lymphoma with a rare radiographic pattern and distinct histologic description that at first misdiagnosed as pulmonary tuberculosis but eventually lung biopsy confirmed diagnosis of pulmonary hodgki...

Non-Hodgkin lymphoma is a heterogeneous group of lympho-proliferative disorders. We performed a meta-analysis to summarize the available evidence from case-control studies and cohort study on the inconsistent association between occupational sun exposure and the risk of non-Hodgkin lymphoma. We searched PubMed, ISI web of science, the Cochrane Library, EMBASE and reference lists for relevant ar...

objective(s): the aim of this study is to evaluate the role of pet-ct in identification of different patterns of extranodal involvement in hodgkin’s disease (hd) and non-hodgkin’s lymphoma (nhl) and to enlist the common sites of extranodal involvement in each histological type and compare our results with the existing literature. methods: in this retrospective study of 281 cases of lymphomas of...