Homer-1c/Vesl-1L is a 48-kDa protein that forms part of a family of conserved Homer-related proteins that interact with the C-termini of the metabotropic glutamate receptors mGluR1alpha and mGluR5. In order to examine the function of Homer-1c, HEK-293 cells have been transfected with mGluR1alpha, Homer-1c, and both proteins together. When cells were transfected with both proteins, biotinylation...

Our previous studies found that Homer 1a, a scaffolding protein localized at the post-synaptic density (PSD) of glutamatergic excitatory synapses, is significantly down-regulated in the brain of spontaneous hypertensive rats (SHR), an animal model of attention deficit hyperactivity disorder (ADHD). Furthermore, a first-line treatment drug for ADHD, methylphenidate, can up-regulate the expressio...

IMPORTANCE Homer proteins are a family of scaffolding proteins of the postsynaptic density. Homer-3 colocalizes and modulates the activity of group I metabotropic glutamate receptors (mGluR1 and mGluR5). Cerebellitis has been reported in association with antibodies to mGluR1. We describe the second patient with cerebellitis and Homer-3 antibodies and report a novel, highly specific immunoblot a...

“Supplementary Figure 1. Effect of activity blockade on synaptic area, levels of Homer and Bassoon, Homer-Bassoon colocalization values in three independent experiments, and the relationship between the colocalization values and synaptic properties. (A) TTX treatment does not affect the size of synaptic clusters. P > 0.05, Mann-Whitney test. (B) TTX treatment increases synaptic levels of Homer....

Homer proteins bind specifically to the C termini of the metabotropic glutamate receptor mGluR1alpha/a and mGluR5, play a role in their targeting and modulate their synaptic properties. We have discovered that extensive alternative splicing generates a family of 17 Homer proteins. These fall into two distinct groups of 12 "long" Homers, which all have a coiled-coil domain at their C termini, an...

Members of the hAT transposable element family are mobile in non-host insect species and have been used as transformation vectors in some of these species. We report that the Queensland fruit fly, Bactrocera tryoni, contains at least two types of insect hAT elements called Homer and a Homer-like element (HLE). The Homer element is 3789 bp in size and contains 12-bp imperfect inverted terminal r...

Case Study Feasibility Analysis of Renewable Energy Supply Systems in a Small Grid Connected Resort By Jody Robins Dr. Robert Woods, Committee Chair Professor of Hotel Management University of Nevada, Las Vegas This paper presents a case study on the feasibility of a small grid connected resort in the marine west coast climate of Canada to implement a renewable energy supply system. The current...

More than a billion people do not have access o electricity, so it is important to find ways generate power close where they live. Hybrid energy systems can be made and used electricity for homes businesses that are connected national or regional grids. yield greater environmental economic returns stand-alone geothermal, solar, wind, bigenerational systems. The goal of this paper simulate hybri...