Mitoxantrone is a marker substrate of breast cancer resistance protein (BCRP). BCRP involved in number pharmacokinetic drug-drug interactions. The transporter’s possible saturability makes it advisable to use low concentrations mitoxantrone for vitro studies. Consequently, quantification requires method with high sensitivity. aim the study was develop and validate procedure Caco-2 culture media...

Introduction. Favipiravir is one of the most well-known broad-spectrum drugs against many RNA viruses, including severe acute respiratory syndrome virus 2 [severe coronavirus (SARS-CoV-2)]. Due to its structure, favipiravir embedded in and blocks further replication cell human body. also included list vital essential medicines, which confirms importance for Russian healthcare this drug fight co...

Abstract “Nanicão Corupá” (Musa acuminata) comes from Southern Brazil. The tropical climate in the region provides unique characteristics, including a sweeter flavor. This difference resulted Geographical Indication Recognition and Designation of Origin, recognized by National Institute Industrial Property (INPI) Considering that has some peculiarities related to there are no studies evaluating...

In this review article determines the different analytical methods for quantitative establishment of Erlotinib by using HPLC, HPLCMS, HPLC-UV, LC-MS/MS. Pharmaceutical method development requires valid procedures and qualitative analysis in Pharmaceuticals dosage formulations human serum. This assessment explains that superiority HPLC/LC-MS reviewed is based on drugs formulations, (API), biolog...

Let X be a (quasi-projective) variety over k. We follow [Sha13, Chap. 6, §1.2].