Glucocorticoids promote the development of many organs including intestine. At the cellular level, the activity of glucocorticoids is regulated by 11 beta-hydroxysteroid dehydrogenase (11 beta HSD) which converts active glucocorticoids to inactive metabolites. As 11 beta HSD is also expressed in the intestine, this enzyme may be an important regulator of intestinal maturation. To investigate th...

AIM 11beta hydroxysteroid dehydrogenase (11beta HSD) catalyzes the interconversion of glucocorticoids to inert metabolites in man and rodents and plays a crucial role in regulating corticosteroid hormone action. The physiological role and regulation of 11beta HSD type 2 in the adrenal gland remains obscure. Therefore, the aim of the present study was to establish the pattern of 11beta HSD type ...

11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) modulates the access of corticosteroids to their receptors and plays an important role in controlling blood pressure. We determined 11 beta-HSD activity and mRNA levels in the mesenteric arteries of genetically hypertensive rats, the Dahl salt-sensitive hypertensive rat, and compared them with Dahl salt-resistant and Sprague-Dawley rats. 11 bet...

Heterodera glycines Hg-hsd-1 and Hg-hsd-2 are two homologues of let-767, a short-chain dehydrogenase gene from the free-living nematode Caenorhabditis elegans. Both genes share similarity to 17β-hydroxysteroid dehydrogenases (17β-HSDs), enzymes known to be involved in the production of steroid hormones in mammals. Hg-hsd-1 and Hg-hsd-2 encode distinct protein sequences that share 51% amino acid...

In androgen target tissues, 3a-hydroxysteroid dehydrogenase (3a-HSD) may regulate occupancy of the androgen receptor (AR) by catalyzing the interconversion of 5a-dihydrotestosterone (5a-DHT) (a potent androgen) and 3a-androstanediol (a weak androgen). In this study, a 3a-HSD cDNA (1170 bp) was isolated from a human prostate cDNA library. The human prostatic 3a-HSD cDNA encodes a 323amino acid p...

Dehydroepiandrosterone (DHEA) is a precursor to sex steroids such as androstenedione (AE), testosterone (T), and estrogens. DHEA has potent effects on brain and behavior, although the mechanisms remain unclear. One possible mechanism of action is that DHEA is converted within the brain to sex steroids. 3 -Hydroxysteroid dehydrogenase/ 54 isomerase (3 -HSD) catalyzes the conversion of DHEA to AE...

The aim of this investigation was to evaluate the influence of a high-salt diet (HSD) on the effects of valsartan, an angiotensin II type 1 (AT(1)) receptor antagonist, on carotid arterial stiffness and structure in spontaneous hypertensive rats (SHR). Carotid arterial stiffness was studied in SHR receiving a HSD or a normal-salt diet (NSD) from the 10th to 20th week of age. Within each of the ...

The cDNAs for two separate human 17,B-hydroxysteroid dehydrogenases (17p-HSD) have been isolated and sequenced. The well-studied human placental cytosolic 17wBHSD (also referred to as estradiol dehydrogenase) preferentially catalyzes the reduction of estrone to estradiol-17/3 and the reduction of the C-20-ketone of progesterone to 20dihydroprogesterone. This isoform of the enzyme has been refer...

The present study examined the hypothesis that hypertonic saline dextran (HSD), given after an initial insult, attenuates exaggerated inflammation that occurs with a second insult. Adult rats (n = 15 per group) were divided into groups 1 (sham burn), 2 [40% total body surface area burn + 4 ml/kg isotonic saline (IS) + 4 ml.kg(-1).% burn(-1) lactated Ringer solution (LR)], and 3 (burn + 4 ml/kg ...

We have investigated the expression of cholesterol side-chain cleavage cytochrome P450 (P450scc) and 3âhydroxysteroid dehydrogenase (3â-HSD) type 1 genes during human trophoblast differentiation in culture and the modulation of their steady-state mRNA levels by steroids. During the first 24 to 48 h after plating, mononucleated cells aggregated, forming colonies. After 60 h in culture, cell diam...