Staphylococcus aureus encodes two HtrA-like serine surface proteases, called HtrA1 and HtrA2. The roles of these HtrA homologs were distinguished by expression studies in a heterologous host, Lactococcus lactis, whose single extracellular protease, HtrA(Ll), was absent. HtrA(Ll) is involved in stress resistance, and processing and/or degradation of extracellular proteins. Controlled expression ...

In their contribution to PNAS, Beaufort et al. demonstrate that high temperature requirement protein A1 (HtrA1) facilitates TGF-β signaling through processing latent TGF-β binding protein 1 (LTBP-1) (1). Then the authors suggest the down-regulation of TGF-β signaling by lack of HtrA1-mediated LTBP-1 processing as a key mechanism underlying pathogenesis of cerebral autosomal recessive arteriopat...

PURPOSE Single nucleotide polymorphisms (SNPs) of age-related maculopathy susceptibility protein 2/HtrA serine peptidase 1 (ARMS2/HTRA1) and complement factor H (CFH) have been reported to be associated with age-related macular degeneration (AMD). The purpose of this study was to investigate the association of ARMS2/HTRA1 and CFH SNPs with early age-related maculopathy (ARM) in a Han Chinese co...

Exudative age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) share similar abnormal choroidal vasculature, but responses to treatments are different. In this study, we sequenced the whole HTRA1 gene and its promoter by direct sequencing in a Hong Kong Chinese PCV cohort. We identified rs11200638, c.34delCinsTCCT, c.59C>T, rs1049331 and rs2293870 significantly ass...

Download artin and tuberin are products of the tumor suppressor genes TSC1 and TSC2, respectively. Mutations ng either gene result in the tuberous sclerosis syndrome, a neurologic genetic disorder characterized by rmation of multiple benign tumors or hamartomas. In this study, we report the identification of TSC2, t TSC1, as a substrate of HtrA1, a member of the human HtrA family proteins of se...

ownload artin and tuberin are products of the tumor suppressor genes TSC1 and TSC2, respectively. Mutations ng either gene result in the tuberous sclerosis syndrome, a neurologic genetic disorder characterized by rmation of multiple benign tumors or hamartomas. In this study, we report the identification of TSC2, t TSC1, as a substrate of HtrA1, a member of the human HtrA family proteins of ser...

Download artin and tuberin are products of the tumor suppressor genes TSC1 and TSC2, respectively. Mutations ng either gene result in the tuberous sclerosis syndrome, a neurologic genetic disorder characterized by rmation of multiple benign tumors or hamartomas. In this study, we report the identification of TSC2, t TSC1, as a substrate of HtrA1, a member of the human HtrA family proteins of se...

HtrA1 (high-temperature requirement protein A1) is a secreted multidomain protein with proven serine protease activity and the ability to regulate TGF-beta (transforming growth factor-beta)/BMP (bone morphogenetic protein) signalling. There is increasing evidence that HtrA1 regulates several pathological processes, including tumour development, Alzheimer's disease, age-related macular degenerat...

The human serine protease high temperature requirement A1 (HTRA1) is highly expressed in the placental tissue, especially in the last trimester of gestation. This suggests that HTRA1 is involved in placental formation and function. With the aim of a better understanding of the role of HTRA1 in the placenta, candidate substrates were screened in a placenta protein extract using a gel-based mass ...

High temperature requirement A1 (HtrA1) is a trypsin-fold serine protease implicated in the progression of age-related macular degeneration (AMD). Our interest in an antibody therapy to neutralize HtrA1 faces the complication that the target adopts a trimeric arrangement, with three active sites in close proximity. In the present study, we describe antibody 94, obtained from a human antibody ph...