Weibull, Claes (Rocky Mountain Laboratory, Hamilton, Mont.). Structure of bacterial L forms and their parent bacteria. J. Bacteriol. 90:1467-1480. 1965.-Light and electron microscopic studies were done on normal cells and L forms of Proteus mirabilis, Staphylococcus aureus, and Corynebacterium sp. grown in liquid media. Under the prevailing growth conditions, the L forms studied were morphologi...

We have been developing computer simulation models of the human body in order to simulate various forms of motions, e.g., walking, standing and jumping. In the earlier phase of our research, we utilized a simulation model of the human lower extremity that has nine rigid body segments. The number of degrees of freedom of the model was twenty. Using this model, two forms of jumping motions were s...

Bacterial expression systems provide economic and logistic advantages in manufacturing proteins for human therapeutic purposes. However, most such proteins accumulate in insoluble biologicaIIy inactive form when overexpressed in bacterial cells. This is the case while attempting to produce recombinant human granulocyte-macrophage colony stimulating factor (hGM-CSF) in E. coli. In this repor...

Joal Hill I read with interest the debate about for-profi t versus non-profi t institutional review boards (IRBs) [1], but was disappointed that no one addressed the ability (or inability) of for-profi t IRBs to review studies with the local context of research subjects in mind and then monitor what actually occurs during the consent process throughout the research trial. To my mind the “bignes...

There is a significant need for research and development into paediatric medicines. Only a small fraction of the drugs marketed and utilized as therapeutic agents in children have been clinically evaluated. The majority of marketed drugs are either not labelled, or inadequately labelled, for use in paediatric patients. The absence of suitable medicines or critical safety and efficacy informatio...

Joal Hill I read with interest the debate about for-profi t versus non-profi t institutional review boards (IRBs) [1], but was disappointed that no one addressed the ability (or inability) of for-profi t IRBs to review studies with the local context of research subjects in mind and then monitor what actually occurs during the consent process throughout the research trial. To my mind the “bignes...

Health Action International (HAI)-Europe and the Dag Hammarskjoeld Foundation jointly convened an International Working Group to seek ways of promoting openness and accountability in drug regulation, both in industrialised and developing countries. The Working Group met in Uppsala, Sweden from 11-14 September 1996. In recent decades, most countries of the world have established agencies to ensu...