Background: Spontaneous ovarian hyperstimulation syndrome rarely occurs during pregnancy and is usually associated with high levels of human chorionic gonadotropin, in conditions such as molar or multifetal pregnancies. Case report: Here we report spontaneous ovarian hyperstimulation in a patient presenting with missed abortion at 16th week of gestation, when serum ß-subunit human chorionic gon...

Background: Human chorionic gonadotropin (hCG) is a member of glycoprotein hormones family consist of two different non-covalently heterodimeric chains: alpha and beta subunits with 92 and 145 amino acids respectively. This hormone plays an important role in human reproduction and physiology especially for maintenance of the corpus luteum during the first months of pregnancy Materials and Metho...

The influence of varying doses of human chorionic gonadotropin (hCG) on the preovulatory luteinizing hormone (LH) surge, estradiol-17 beta (E2) and progesterone (P4) was studied in synchronized gilts. Altrenogest (AT) was fed (15 mg X head-1 X d-1) to 24 cyclic gilts for 14 d. Pregnant mares serum gonadotropin (PMSG; 750 IU) was given im on the last day of AT feeding. The gilts were then assign...

In type 1 diabetes mellitus, the impaired testosterone synthesis in testes leads to androgen deficiency. The long-term application of high gonadotropin doses for its correction decreases sensitivity luteinizing hormone/human chorionic (LH/hCG) receptors Leydig cells endogenous gonadotropins. aim this work was study effect a 3-day treatment male Wistar rats with streptozotocin 5-amino- N-tert -b...

OBJECTIVE We propose that the adrenal gland of an older higher primate female animal model will respond to human chorionic gonadotropin (hCG) hormone challenge by secreting additional dehydroepiandrosterone sulfate (DHEAS). Such a response in surgically and chemically castrated animals will provide proof of concept and a validated animal model for future studies to explore the rise in DHEAS dur...

BACKGROUND Human luteinizing hormone (LH) and chorionic gonadotropin (hCG) are glycoprotein hormones regulating development and reproductive functions by acting on the same receptor (LHCGR). We compared the LH and hCG activity in gonadal cells from male mouse in vitro, i.e. primary Leydig cells, which is a common tool used for gonadotropin bioassay. Murine Leydig cells are naturally expressing ...

The physical properties of detergent-solubilized gonadotropin receptor-hormone complexes, determined by density gradient centrifugation and gel filtration, were compared after in vivo and in vitro labeling of specific ovarian binding sites with radioiodinated human chorionic gonadotropin (hCG). Following intravenous administration of biologically active 125I-labeled hCG, up to 50% of the gonado...

OBJECTIVE The aim of the present study was to evaluate the effects of fetal gender on serum human chorionic gonadotropin (hCG) and testosterone in normotensive and preeclamptic pregnancies. METHODS The study consisted of 137 women with singleton pregnancies in the third trimester. Seventy-three pregnancies were uncomplicated; among those were 35 male and 38 female fetuses. Sixty-four pregnanc...

It is now evident that human chorionic gonadotropin (hCG) is not a single molecular entity but consists of a number of different biologically active components [l-4]. By means of gel isoelectric focusing 6 hCG forms recently could be isolated and characterized [2-41. Furthermore it is well established that hCG is composed of 2 subunits: hCG-a (common to other proteohormones) and hCH-fl (hormone...