A plant viral vector engineered from an in vivo infectious clone of zucchini yellow mosaic virus(ZYMV) was used to express the human interferon-gamma (INF-γ) in planta. The INF-γ gene was in frame inserted between the P1 and HC-Pro ORFs of the ZYMV vector. The infectious activity of the vector was approved by rubbing the plasmid on Chenopodium quino a and observing local lesions. Individual les...

Abstract Immune defenses are triggered by cytokines like interferon-α (IFN-α) and IFN-γ in diverse cells. Both IFNs induce a class of factors termed IFN-stimulated genes (ISGs). Many ISG proteins have antiviral functions. There is growing appreciation that repertoires cell-type specific this bias impacts infection outcomes. However, the cues mechanisms driving these variable responses ill-defin...

not received.[15.20–15.40]Comparison of rituximab-mediated interferon-γproduction and cytotoxicity by human NK cellsSébastien Dall’Ozzo, Pierre Bardos, Hervé Watier and

BACKGROUND : Interferon-gamma (INF-γ) is an important cytokine in the immune response against Mycobacterium tuberculosis. activates macrophage to kill intracellular mycobacterium. AIM: The aim of this study determine difference plasma INF-γ level pulmonary tuberculosis (PTB) patients compared a healthy control and factors associated with interferon-gamma level. METHODS: This case–control study....

a plant viral vector engineered from an in vivo infectious clone of zucchini yellow mosaic virus(zymv) was used to express the human interferon-gamma (inf-γ) in planta. the inf-γ gene was in frame inserted between the p1 and hc-pro orfs of the zymv vector. the infectious activity of the vector was approved by rubbing the plasmid on chenopodium quino a and observing local lesions. individual les...

Tumour necrosis factor-α, interferon-γ and interleukin-4 are critical cytokines in regulating the immune responses against infections and tumours. In this study, we investigated the effects of three cytokines on CD40 expression in Myb-transformed hematological cells and their regulatory roles in promoting these cells into dendritic cells. We observed that both interleukin-4 and interferon-γ inc...

Background: Cutaneous leishmaniasis (CL) is a self-healing disease, but due to unknown causes, a few cases of CL could get a chronic or non-healing course. These cases of chronic and recurrent leishmaniasis are defined as non-healing. Objectives: Comparison of the production of interferon-γ (IFN-γ) and Leishmanin skin test (LST) between non-healing and healed patients of CL. Patients and ...

The cytokine interferon gamma (IFN-γ) and doxorubicin mono-therapy has been approved by the Food Drug Administration (FDA) for treatment of tumors. importance IFN-γ in immune system lies its immunomodulatory effects, antitumor therapy inhibiting RNA DNA synthesis. In this work, role activity combination with was investigated. Meanwhile, used as a vehicle to load over immunotherapy chemotherapy ...

The Immunogenicity of γ-irradiated tachyzoites of a highly virulent strain of Toxoplasma gondii (RH strain) was investigated. Immunized mice survived challenge infection and displayed increased interferon gamma (INF-γ ) production. On the other hand, nonimmunized controls died after 10 days and displayed a significantly decreased lymphoproliferative response to Concanavalin A (Con A). No tachyz...