the genes glutathione s-transferase m1 (gstm1) and gstt1 code for cytosolic enzymes gstµ and gstθ, respectively, which are involved in phase ii metabolism. in human, both genes may be deleted. in the present study, the genetic polymorphisms of gstm1 and gstt1 were detected by pcr method in 236 healthy individuals from shiraz population, fars province, south of iran. the frequency of gstm1 and g...

in general, both common illnesses and rare diseases can develop in people and their relatives in families. therefore, taking family history is an effective screening tool to detect such diseases and patients should be aware of its importance in families’ health with updating information in regular visiting. for more information on identifying the genetic pattern of diseases, in this article, we...

Patterns of genetic variability in human populations are profoundly influenced by social organisation, including lifestyle, language, religion and social status. A nice illustration is seen among societies that have specific rules about who can marry whom.

We studied human population structure using genotypes at 377 autosomal microsatellite loci in 1056 individuals from 52 populations. Within-population differences among individuals account for 93 to 95% of genetic variation; differences among major groups constitute only 3 to 5%. Nevertheless, without using prior information about the origins of individuals, we identified six main genetic cluste...

This unit describes the isolation of monocytes from lymphocytes by adherence, gradient sedimentation on colloidal silica particles, and flow cytometry. Because the first two methods can result in cell activation (induction of gene expression or protein secretion), and the third is technically difficult, a fourth protocol is presented which describes counterflow centrifugal elutriation. This lat...

Whereas the human linkage map appears on limited evidence to be constant over populations, maps of linkage disequilibrium (LD) vary among populations that differ in gene history. The greatest difference is between populations of sub-Saharan origin and populations remotely derived from Africa after a major bottleneck that reduced their heterozygosity and altered their Malecot parameters, increas...