background and objectives: angiogenesis is essential for tumor survival. inhibiting angiogenesis could be a mechanism for hindering tumor development. numerous studies have now been focused on agiogenesis inhibitors and many of such studies have targeted plant materials. in the present study, crocus pallasii subsp. haussknechtii has been evaluated for anti-angiogenesis properties. methods: anti...

The upregulated kinin B1 receptors exert a pivotal role in modulating inflammatory processes. In isolated human umbilical veins (HUVs), kinin B1 receptor is upregulated as a function of in vitro incubation time and proinflammatory stimuli. The aim of this study was to evaluate, using functional and biochemical methods, the involvement of extracellular signal-regulated kinase 5 (ERK5), p38 mitog...

Vascular endothelial growth factor165 (VEGF165) and semaphorin3A (SEMA3A) elicit pro- and antiangiogenic signals respectively in endothelial cells (ECs) by binding to their receptors VEGFR-2, neuropilin-1 (NRP1), and plexin-A1. Here we show that the VEGF165-driven angiogenic potential of multiple myeloma (MM) ECs is significantly higher than that of monoclonal gammopathy of undetermined signifi...

This paper presents a very special cutting path determination problem appearing in a high precision tools factory, and provides two new heuristics for its resolution. Particular features of both the cutting process, and of the material to be cut, bring in a set of unusual constraints, when compared with other cutting processes, which confer additional complexity and originality to the problem. ...

A mechanically sound and compliant biomaterial with superior cell adhesion and remodeling capabilities would be an ideal tissue engineering scaffold. Although processed ex vivo tissues have many of these desired qualities they have seen limited use primarily due to the lack of physical uniformity and tediousness, time consuming preparation methodologies. In this investigation, a novel method fo...