نتایج جستجو برای: hwp1 gene
تعداد نتایج: 1141419 فیلتر نتایج به سال:
کاندیدا آلبیکنس یک قارچ فرصت طلب وشایع ترین عامل پاتوژن قارچی انسان است. ژنهای متعددی ازقبیلhwp1 (پروتئین دیواره سلولی هایفی)درروند پاتوژنیسیته این قارچ موثرند. ژن hwp1،یک عامل شناخته شده ای درکاندیدا آلبیکنس است که این پروتئین دیواره سلولی باعث تشکیل بیوفیلم می شود. در این تحقیق به بررسی حضور ژن hwp1 کاندیدا آلبیکنس در ایزوله های بدست آمده از زنان مبتلا به واژنیت کاندیدیازیس و نقش آن در اتصال ...
Cell wall proteins are central to the virulence of Candida albicans. Hwp1, Hwp2 and Rbt1 form a family of hypha-associated cell surface proteins. Hwp1 and Hwp2 have been involved in adhesion and other virulence traits but Rbt1 is still poorly characterized. To assess the role of Rbt1 in the interaction of C. albicans with biotic and abiotic surfaces independently of its morphological state, het...
Proteins that are covalently linked to the skeletal polysaccharides of the cell wall of Candida albicans play a major role in the colonization of the vaginal mucosal surface, which may result in vaginitis. Here we report on the variability of the cell-wall proteome of C. albicans as a function of the ambient O(2) concentration and iron availability. For these studies, cells were cultured at 37 ...
Antifungal resistance and virulence properties of Candida albicans are a growing health problem worldwide. To study the expression of virulence and azole resistance genes in 39 clinical strains of C. albicans, we used a model of infection of human vaginal epithelial cells with C. albicans strains isolated from Mexican women with vulvovaginal candidiasis (VVC). The strains were identified by PCR...
The study of gene regulation in many organisms has been facilitated by the development of reporter genes. The authors report the use of lacZ from Streptococcus thermophilus, a gene encoding a beta-galactosidase, as a reporter for the fungal pathogen Candida albicans. As test cases, Strep. thermophilus lacZ was placed under control of three different C. albicans promoters: MAL2 (maltase), induci...
OBJECTIVE The principal aim of this study was to investigate the in vitro co-infection of a reconstituted human vaginal epithelium (RHVE) by Candida albicans and Candida glabrata. METHODS The ability of both species to invade and colonise the RHVE was examined using species-specific peptide nucleic acid (PNA) probe hybridisation, confocal laser scanning microscopy (CLSM) and a novel qRT-PCR p...
/ کاندیدا آلبیکنس به صورت بیوفیلم، به عنوان یکی از مهمترین پاتوژن های قارچی انسان شناخته شده است و بیشتر مطالعات مولکولی بر ژن های عامل تشکیل بیوفیلم در این گونۀ مخمری صورت گرفته است. عفونت واژینال از جمله شایع ترین عفونت ها در میان زنان است. چنین به نظر می رسد که دو ژن als1 و hwp1 نقش مهمی در ایجاد بیوفیلم این گونه قارچی داشته باشند. هدف از این پژوهش، بررسی مقایسه ای دو ژن als1 و hwp1 جدایه ها...
Candida albicans triggers recurrent infections of the oropharyngeal mucosa that result from biofilm growth. Prior studies have indicated that the transcription factor Bcr1 regulates biofilm formation in a catheter model, both in vitro and in vivo. We thus hypothesized that Bcr1 plays similar roles in the formation of oral mucosal biofilms and tested this hypothesis in a mouse model of oral infe...
Streptococcus agalactiae and Candida albicans often co-colonize the female genital tract, and under certain conditions induce mucosal inflammation. The role of the interaction between the two organisms in candidal vaginitis is not known. In this study, we found that co-infection with S. agalactiae significantly attenuated the hyphal development of C. albicans, and that EFG1-Hwp1 signal pathway ...
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