BACKGROUND It is proposed that chronic calcineurin inhibitor (CNI) nephrotoxicity has a central role in chronic kidney disease after nonrenal solid organ transplantation (NRSOT), although there are little data on renal histology in this setting. The aim of this study was to assess the histological features and renal outcomes of a cohort of patients with chronic kidney disease after NRSOT. MET...

BACKGROUND Primary focal segmental glomerulosclerosis (FSGS) is defined by the presence of proteinuria, often in nephrotic range and pathologically by segmental scars (SS). The aim of this study is to identify the possible predictors of complete remission or progression to chronic kidney disease in Iranian adults with primary focal segmental glomerulosclerosis. METHODS In this historical coho...

1. George F, Brisson C, Poncelet P, et al. Rapid isolation of human endothelial cells from whole blood using S-Endo1 monoclonal antibody coupled with immunomagnetic beads: demonstration of endothelial injury after angioplasty. Thromb Haemost. 1992;67:147-153. 2. Rambaud JC, Galian A, Touchard G, et al. Digestive tract and renal small vessel hyalinosis, idiopathic nonarteriosclerotic intracerebr...

BACKGROUND Hyperuricemia frequently complicates cyclosporine (CsA) therapy. Previous studies have shown that hyperuricemia exacerbates interstitial and vascular lesions in the cyclosporine model. We tested the hypothesis that normalization of uric acid could prevent the development of cyclosporine toxicity. METHODS CsA nephropathy was induced by administering CsA (15 mg/kg/day) for 7 weeks to...

Background. Hyaline fibromatosis syndrome is a rare, highly dramatic, autosomal recessive multisystem disorder. The basis of the disease abnormal diffuse deposition hyaline material in connective tissue and internal organs. Mutations CMG2 gene (also known as ANTXR2 gene) cause disease. encodes transmembrane protein involved endothelial development. involves two allelic diseases that have same p...

Twelve miniature pigs were inoculated with an attenuated African swine fever virus to study glomerular involvement in surviving pigs. In acute phase, kidneys were severely affected and displayed a glomerular capillary thrombosis with fibrin deposition in vascular lumen, detected by immunofluorescence. Fibrin-positive deposits were progressively cleared between one to three months after infectio...