The use of intra-articular hydrocortisone acetate in the treatment of osteo-arthritis has been shown to produce a temporary improvement of symptoms in many cases (Hollander, Stoner, Brown, and De Moor, 1951), although enthusiasm for this method has been tempered by warnings of the possibility of increasing the damage in joints subjected to excessive use in the periods of freedom from symptoms (...

  Occurrence of adhesions after pelvic and abdominal surgery is a well known problem. Previous surgical procedures are by far the most common cause of intra abdominal a adhesion. In over  10℅ of infertile women, adhesion formation is the main cause of their problem. Moreover postoperative adhesions are the most common cause of intestinal obstruction in the Western world. Although the cause of ...

To elucidate mechanisms underlying the prolonged monocytopenia induced in the peripheral blood of mice by injection of a subcutaneous depot of hydrocortisone acetate, the effect of this compound on the production of monocytes and their release from the bone marrow was studied. Hydrocortisone was found to cause a rapid reduction of the bone marrow promonocytes to about 65% of their initial numbe...

The effect of corticosteroid on autologous minced cartilage transplanted into facsimile synovial cavities has been studied. The soluble form of hydrocortisone, as the sodium succinate, reduced proteoglycan loss from cartilage in a dose-dependent manner. In contrast, insoluble hydrocortisone acetate, if given directly into the cartilage-containing cavity, enhanced proteoglycan loss. Injection of...

It has previously been shown that in most joint diseases changes occur in the hyaluronic acid in the joint fluid. In diseased fluids the hyaluronic acid has a considerably lower degree of polymerization than in normal fluids or in uncomplicated traumatic effusions (Sundblad, 1953). The hyaluronic acid changes are especially marked in rheumatoid arthritis. We recently demonstrated (Sundblad, Ege...