In the current work, we demonstrate how coordination chemistry can be employed to direct self-assembly based on strong hydrophobic interactions. To investigate the influence of coordination sphere geometry on aqueous self-assembly, we synthesized complexes of the amphiphilic perylene diimide terpyridine ligand with the first-row transition-metal centers (zinc, cobalt, and nickel). In aqueous me...

The principles obtained from studies on molecular chaperones have provided explanations for the assisted protein folding in vivo. However, the majority of proteins can fold without the assistance of the known molecular chaperones, and little attention has been paid to the potential chaperoning roles of other macromolecules. During protein biogenesis and folding, newly synthesized polypeptide ch...

In the present work, we have explored the use of the triphenylmethyl group, a commonly used protecting group for primary alcohols as a gelling structural component in the design of molecular gelators. We synthesized a small library of triphenylmethyl derivatives of simple primary alcohols and studied their gelation properties in different solvents. Gelation efficiency for some of the derivative...

block copolymer nano-micelles are especially important in cancer treatment because of their fine dimensions. in this article, three systems of amphiphilic copolymers with similar lengths and different ratios of the hydrophobic and hydrophilic chains are studied using implicit-solvent coarse-grained molecular dynamics simulations. the factor fphil is defined as the ratio of the number of hydroph...

The interaction between two associating hydrophobic particles has traditionally been explained in terms of the release of entropically frustrated hydration shell water molecules. However, this picture cannot account for the kinetics of hydrophobic association and is therefore not capable of providing a microscopic description of the hydrophobic interaction (HI). Here, Monte Carlo simulations of...

We created a homology model of the homo-tetrameric pore domain of HERG using the crystal structure of the bacterial potassium channel, KvAP, as a template. We docked a set of known blockers with well-characterized effects on channel function into the lumen of the pore between the selectivity filter and extracellular entrance using a novel docking and refinement procedure incorporating Glide and...

Interpenetrating polymer networks (IPN) were formed involving hydrophobic polybutyl acrylate (PBA) and hydrophilic poly hydroxyethyl acrylate (PHEA). PBA prepolymer was first formed in presence of ferric oxide nanoparticles (

Interpenetrating polymer networks (IPN) were formed involving hydrophobic polybutyl acrylate (PBA) and hydrophilic poly hydroxyethyl acrylate (PHEA). PBA prepolymer was first formed in presence of ferric oxide nanoparticles (

due to poor solubility in lipids, many of bioactive components (nutraceutical materials) show less bioactivity than optimal state in water solution. phytosomes improve absorption and bioavailability of biomaterials. liposomes, spherical shaped nanocarriers, were discovered in the 1960s by bangham. due to their composition, variability and structural properties, liposomes and phytosomes are extr...