We have previously shown that the pulmonary venoconstriction produced by a stable thromboxane A2 analogue (STAJ is attenuated by prostacyclin (PGIi), but PGI, increases the STA2-induced edema. The present study was designed to determine the effects of STA2 and PGI2 on the fluid balance in isolated blood-perfused newborn lamb lungs. Vascular permeability was evaluated by use of the fluid filtrat...

Human osteosarcoma cells, MG-63, were exposed to a hydrostatic pressure shock of 4.0 MPa for 20 min. Changes in subcellular distribution of the cytoskeletal elements and heat shock protein 70 (hsp70) were followed by indirect immunofluorescence and by avidin-biotin-peroxidase protocols. During recovery, total cellular RNA was determined and actin and aldolase mRNA content was followed using rev...

Intermittent tongue, lip and cheek forces influence precise tooth position, so we here examine the possibility that tissue remodelling driven by functional bite-force-induced jaw-strain accounts for tooth eruption. Notably, although a separate true 'eruptive force' is widely assumed, there is little direct evidence for such a force. We constructed a three dimensional finite element model from a...

Skeletal regeneration is accomplished by a cascade of biologic processes that may include differentiation of pluripotential tissue, endochondral ossification, and bone remodeling. It has been shown that all these processes are influenced strongly by the local tissue mechanical loading history. This article reviews some of the mechanobiologic principles that are thought to guide the differentiat...

Models currently used to simulate the impact behaviour of polymeric foam at high strain rates use data from mechanical tests. Uniaxial compression is the most common mechanical test used, but the results from this test alone are insufficient to characterise the foam response to three-dimensional stress states. A new experimental apparatus for the study of the foam behaviour under a state of hyd...

In this paper, the basic governing equations for isotropic and homogeneous generalized thermoelastic half-space under hydrostatic initial stress are formulated in the context of the Green and Naghdi theory of types II and III. These governing equations are solved analytically to obtain the dimensional velocities in an xy-plane. It is shown that there exist three plane waves, namely a thermal wa...

SOME CONWJWENCX~ of a simple theoretical model for the stress-induced, isothermal phase transformation of an isolated tetragnnal zirconia crystal are studied. The transformation to a monoclinic state is viewed as mechanical buckling from one homogeneous geometrical configuration to another. The model is used to predict the manner in which an applied shear stress should interact with hydrostatic...

Our previous studies have shown that hydrostatic pressure can serve as an active regulator for bone marrow mesenchymal stem cells (BMSCs). The current work further investigates the roles of cytoskeletal regulatory proteins Ras homolog gene family member A (RhoA) and Ras-related C3 botulinum toxin substrate 1 (Rac1) in hydrostatic pressure-related effects on BMSCs. Flow cytometry assays showed t...

The effect of overpressure on gas hydrate and free gas distribution in marine sediments is studied using a one-dimensional numerical model that couples sedimentation, fluid flow, and gas hydrate formation. Natural gas hydrate systems are often characterized by high sedimentation rates and/or low permeability sediments, which can lead to pore pressure higher than hydrostatic (overpressure). To q...

Vascular endothelial cells are exposed to a variety of in vivo mechanical forces, specifically, shear stress for the blood flow, tensile stress from the compliance of the vessel wall and the hydrostatic pressure from containment of blood within inside the vasculature. Many authors studied hemodynamic, functional and morphological human saphenous veins alterations caused by these different force...