HYPOTHESIS Adrenal vein sampling is superior to computed tomography for subtype differentiation of primary hyperaldosteronism. DESIGN Retrospective review. SETTING University medical center. PATIENTS Forty-eight patients (32 men and 16 women) with biochemically confirmed primary hyperaldosteronism. MAIN OUTCOME MEASURES We compared demographic factors, results of biochemical and imaging...

In primary hyperaldosteronism, it is important to distinguish between unilateral and bilateral disease, as management strategies differ. In the period 1983-95, we identified 34 patients with primary hyperaldosteronism. Following further investigations, a diagnosis of aldosterone-secreting adenoma was made in 17 patients, and surgery was performed. Computed tomography clearly localized an appare...

Cirrhotic ascites, in which secondary hyperaldosteronism is a notable feature, is associated with impaired gastric secretion (Baddeley, 1968). Obstruction to hepatic venous outflow, which also induces secondary hyperaldosteronism and ascites (Orloff, Ross, Baddeley, Nutting, Spitz, Sloop, Neesby, and Halasz, 1964), depresses acid secretion from Heidenhain pouches in dogs with cirrhotic and non-...

Conn's syndrome due to an adrenal adenoma is very rare in children. This paper reports a 14-year-old boy with primary hyperaldosteronism due to an adrenal adenoma. His biochemistry data were compatible with either bilateral adrenal hyperplasia or an adrenal adenoma. A dexamethasone test did not suppress aldosterone levels. Venous catheter sampling and 75Se-selenomethylcholesterol scanning sugge...

We have shown previously that patients with resistant hypertension and hyperaldosteronism have increased brain natriuretic peptide suggestive of increased intravascular volume. In the present study, we tested the hypothesis that hyperaldosteronism contributes to cardiac volume overload. Thirty-seven resistant hypertensive patients with hyperaldosteronism (urinary aldosterone 12 g/24 hours and p...

OBJECTIVE To determine the frequency of nonfunctioning adrenal masses in patients with primary hyperaldosteronism. DESIGN A case series. SETTING A tertiary care hypertension clinic. PATIENTS Twenty-seven consecutive patients with primary hyperaldosteronism. MEASUREMENTS Blood pressure, serum electrolytes, supine and upright plasma renin, cortisol and aldosterone levels, selective adrena...

Hypertension is defined as average systolic blood pressure and/or diastolic blood pressure that are ≥95th percentile for gender, age, and height on ≥3 occasions (1). Renal parenchymal disease and essential hypertension are the most important causes in <12 and >12 years, respectively (2). Hypertension with hypokalaemia and suppression of plasma renin activity is known as mineralocorticoid hypert...

AIMS Hyperaldosteronism is associated with vascular injury and increased cardiovascular events. Bone marrow-derived endothelial progenitor cells (EPCs) play an important role in endothelial repair and vascular homeostasis. We hypothesized that hyperaldosteronism impairs EPC function and vascularization capacity in mice and humans. METHODS AND RESULTS We characterized the effects of aldosteron...

We present the first report of primary hyperaldosteronism in childhood due to unilateral macronodular hyperplasia. A 10-year-old white boy with severe hypertension (150/100 mm Hg), hypokalemia (1.4 mEq/liter), and suppressed plasma renin activity (PRA) (less than 0.1 ng/ml/hr) demonstrated fixed PRA and aldosterone (aldo) levels that did not change with alteration of dietary sodium. The paradox...