1 Antoniou KM, Ferdoutsis E, Bouros D. Interferons and their application in the diseases of the lung. Chest 2003; 123:209–216 2 Interferonin the idiopathic hypereosinophilic syndrome: consideration of five cases. Ann Hematol 1998; 77:161–164 3 Baratta L, Afeltra A, Delfino M, et al. Favorable response to high-dose interferonin idiopathic hypereosinophilic syndrome with restrictive cardiomyopath...

IMPORTANCE Wells syndrome (WS) (eosinophilic cellulitis) is an uncommon eosinophilic dermatitis that has been rarely described in association with, but distinct from, hypereosinophilic syndrome (HES). OBSERVATIONS We report a case of an eosinophilic dermatosis with flame figures in association with idiopathic HES, manifested by inflammatory myocarditis, asthma, and peripheral blood eosinophil...

We present the case of a 48-year-old female with acute onset altered mental status, who was found to have eosinophilia, elevated troponin, and embolic strokes. Extensive testing for autoimmune, infectious, and coronary artery etiologies was unremarkable. After a cardiac MRI revealed focal myocardial hyperenhancement, the patient underwent an endomyocardial biopsy with findings consistent with e...

Clinical and biological features of patients with the idiopathic hypereosinophilic syndrome (HES) are heterogeneous. Recent evidence suggests at least two distinct underlying hematological disorders involving myeloid and lymphoid cells, respectively. We therefore suggest that the term idiopathic should be abandoned in the classification of HES. This review defines the "myeloproliferative" and "...

Idiopathic hypereosinophilic syndrome is a myeloproliferative disorder with unexplained prolonged eosinophilia and marked predilection for involving multiple organs, especially the heart. Respiratory symptoms often mimic other commoner pulmonary disease states, leading to a diagnostic dilemma and delay in treatment initiation. We report here a case of hypereosinophilic syndrome in a young male ...

Eosinophil-associated diseases represent a spectrum of heterogeneous disorders, where blood and cutaneous eosinophilia is the most important feature and eosinophils are the principal cause of cutaneous lesions. These diseases show some similarities in the clinical features but also many distinctive characteristics [Saurat et al., Dermatologia e malattie sessualmente trasmesse, Milano, Masson, 2...

Objectives: To report a case of hypereosinophilic syndrome which presented clinically as acute coronary syndrome. Materials and methods: We describe the case of a 69-year-old woman with acute coronary syndrome and peripheral hypereosinophilia. Results: The condition rapidly evolved to severe heart failure. Coronary disease was excluded by cardiac catheterization. Systemic corticosteroid therapy...

Hypereosinophilic syndrome (HES) is a rare disorder that is characterized by persistent and marked eosinophilia combined with organ system dysfunction. HES has substantial clinical heterogeneity but can be fatal without treatment, especially in patients who present with a myelodysplastic variant of the disorder. Although the pathophysiology of HES is poorly defined, dysregulation of cytokines (...