Premature ovarian failure (POF) is characterized by hypergonadotropic hypogonadism and amenorrhea before the age of 40. The condition has a heterogeneous background but genetic factors are demonstrated by the occurrence of familial cases. We identified a mother and daughter with POF both of whom carry an X;autosome translocation [t(X;11)(q24;q13)]. RNA expression studies of genes flanking the X...

OBJECTIVE Deficiency of sex steroids has a negative impact on bone mineral content. In studies conducted on postmenopausal women and animal studies, elevated follicle-stimulating hormone (FSH) levels were found to be correlated with a decrease in bone mineralization and osteoporosis. The aim of the present study was to evaluate bone mineral density (BMD) in adolescent girls with hypogonadotropi...

Pituitary causes of amenorrhea should be considered in women with low or normal gonadotropin levels. Pituitary causes of amenorrhea constitute 18% of cases of secondary amenorrhea and 7% of cases of primary amenorrhea (1). Hyperprolactinemia is the most common cause of pituitary amenorrhea, comprising 15% of all cases of secondary amenorrhea and 80% of pituitary cases of secondary amenorrhea (2...

OBJECTIVE To investigate the causes of amenorrhea in Korean women. METHODS Medical records from 1,212 women with amenorrhea who visited the Department of Obstetrics and Gynecology, Asan Medical Center, between January 1989 and December 2011 were retrospectively reviewed. Amenorrhea was categorized as either primary or secondary. RESULTS Primary amenorrhea was identified in 132 of the patien...

Background: The objectives of this study were to determine the etiologic causes of amenorrhea, the prevalence of müllerian anomalies as a cause of primary amenorrhea and the different varieties of müllerian anomalies causing primary amenorrhea. Methods: This study included all the women presenting with primary amenorrhea who presented to the department of obstetrics and gynecology, Nalanda Medi...

Introduction: During puberty, menarche represents the most important event in females. Amenorrhea is defined as the absence of menstruation during puberty. Aim: To evaluate the adolescents with amenorrhea and to analyzed the management of these patients. Material and method: We analyzed 216 patients admitted to the Endocrinology Department over a period of five years, from 2007 to 2012. The stu...

Both hypergonadotropic hypogonadism and myasthenia gravis can be parts of type II autoimmune polyendocrine syndrome and association between the two disorders has been reported in few cases. A 14 year old male patient with a personal history of bilateral cryptorchidism and ptosis was referred for delayed puberty. Clinical examination revealed eunuchoid habitus, small, soft testes, gynecomastia, ...

UNLABELLED Sex chromosome tetrasomy and pentasomy conditions occur in 1:18,000-1:100,000 male births. While often compared with 47,XXY/Klinefelter syndrome because of shared features including tall stature and hypergonadotropic hypogonadism, 48,XXYY, 48,XXXY and 49,XXXXY syndromes are associated with additional physical findings, congenital malformations, medical problems and psychological feat...

Menstrual irregularity is a common occurrence during adolescence, especially within the first 2-3 years after menarche. Prolonged amenorrhea, however, is not normal and can be associated with significant medical morbidity, which differs depending on whether the adolescent is estrogen-deficient or estrogen-replete. Estrogen-deficient amenorrhea is associated with reduced bone mineral density and...