It has been shown that all-trans retinoic acid (ATRA) at doses of 45 to 100 mg/m2/d induces complete remission (CR) of acute promyelocytic leukemia (APL) by a differentiation process. To date, ATRA dose-ranging studies have not yet been evaluated. Thus, we initiated in May 1990 a multicenter study with ATRA at a lower dose of 25 mg/m2/d until CR. Thirty patients with APL were treated with ATRA,...

BACKGROUND No comprehensive data on the clinical features and the prognosis of cerebral malaria in the South Pacific are available at present. We conducted a prospective study in children with cerebral malaria to assess the case fatality rate (CFR) in the region and to identify potential risk factors for death. METHODS We recruited 134 children admitted to the Madang General Hospital between ...

BACKGROUND Neonatal leukemia is a rare disease with an estimated prevalence of about one to five in a million neonates. The majority being acute myeloid leukemia (AML), neonatal leukemia can present with a variety of symptoms including hyperleucocytosis, cytopenia, hepatosplenomegaly, and skin infiltrates. Chromosomal rearrangements including mixed lineage leukemia (MLL) translocations are comm...

Background: The novel coronavirus disease COVID-19 targets mainly the respiratory system, but may in severe cases affect other organs, causing, multiorgan damage, including cardiac injury and acute kidney (AKI). aim of study was to determine prevalence AKI urinary sediment abnormalities patients with evaluate associated factors outcomes hospitalized patients. Material Methods: All laboratory-co...

Biologically, Acute myeloid leukemia (AML) is highly heterogenous. AML with cup-like blast morphology variant has been reported to have important role in risk group stratification and treatment implications. In pediatric age group, this morphology and its clinical implication is rarely discussed. Although this morphology variant is not stated in World Health Organization (WHO) classification of...

BACKGROUND Human coronavirus HKU1 (HCoV-HKU1), a new group 2 coronavirus, was first characterized in 2005 from 2 adults with pneumonia in Hong Kong, China. To the best of our knowledge, there is no other report to date about the detection of this new virus. We report a molecular method allowing for the detection of HCoV-HKU1 and also report the clinical presentation of 6 infected patients. ME...

BEFoRE severing the cervical sympathetic nerve in the rabbit's neck, Claude Bernard had expected that the result of this operation would be a decrease in the temperature of the affected side of the head. His hypothesis was false, but the observed fact, the increase in temperature, was unmistakable. The full significance of the experiment was, to him, initially concealed. To no less extent did i...

Lactic acidosis is a common cause of metabolic acidosis with high anion gap and is a potentially lethal complication of a number of diseases. It develops as a result of an imbalance between lactate production and utilization. Malignancies are a relatively uncommon cause between lactate production and utilization. Malignancies are a relatively uncommon cause. 18 An 84 year old woman was admitted...

Background: The differentiation between infection and aseptic inflammation is difficult often a challenge in the daily practice of rheumatology.Procalcitonin (PCT) preferred marker for bacterial infections that allows rheumatologist to make an early diagnosis, choose appropriate antibiotic therapy infection, avoid unnecessary inflammation. Objectives: To study levels PCT various inflammatory st...

Chronic neutrophilic leukemia (CNL) is a BCR::ABL1-negative myeloproliferative neoplasm (MPN) characterized by sustained peripheral blood (PB) neutrophilia (white cell count ≥ 25×109/L, with ≥80% neutrophils), bone marrow (BM) hypercellularity due to granulocyte proliferation without excess of blast or dysplasia. Somatic mutations CSF3R gene, encoding the colony stimulating factor (G-CSF) recep...