BACKGROUND Dementia affects an estimated 10% of the population older than 65 years. Because vascular and lipid-related mechanisms are thought to have a role in the pathogenesis of Alzheimer's disease and vascular dementia, we did an epidemiological study of the potential effect of HMGCoA (3 hydroxy-3methylglutaryl-coenzyme A) reductase inhibitors (statins) and other lipid-lowering agents on dem...

A patient with sea-blue histiocytosis in spleen and bone marrow with an accompanying hyperlipidaemia is described. The hyperlipidaemia was due to an increase in "free" cholesterol, lecithin, and triglycerides. Despite these findings lecithin-cholesterol acyl transferase activity was normal. Although the precise biochemical defect was not identified, there was a failure of transport of cholester...

About 30",, of patients seen in our lipid clinic during 1976 had raised blood pressure, and many patients attending the hypertension clinic have hyperlipidaemia. This apparent association between hypertension and hyperlipidaemia could have arisen because hypertensives tend to have lipid concentrations measured more frequently than people with no risk factors for vascular disease, or might have ...

Macnamara, B. G. P., Farn, K. T., Mitra, A. K., Lloyd, J. K., and Fosbrooke, A. S. (1970). Archives of Disease in Childhood, 45, 553. Progeria: case report with long-term studies of serum lipids. A girl with the typical features of progeria died at the age of 10 years from cardiac failure following repeated myocardial infarctions. Serial studies of the serum lipids were made from the age of 2 y...