BACKGROUND Anticonvulsant hypersensitivity syndrome (AHS) is a serious but poorly understood and little known disease. It has been variously described in the literature since 1934. Fatalities are rare but have been reported. METHODS A MEDLINE search was undertaken from 1991 to present, using the keywords "anticonvulsant," "phenytoin," and "hypersensitivity." English language articles and thei...

Anticonvulsant hypersensitivity syndrome (AHS) is an uncommon but potentially fatal adverse effect that can occur from exposure to phenytoin, carbamazepine, or phenobarbital. It has diverse clinical features and a variable presentation which results in a delay in making the diagnosis. The syndrome commonly begins within 3 weeks after initiation of an anticonvulsant. Patients typically present w...

BACKGROUND The liver is the most commonly involved internal organ in drug-induced systemic hypersensitivity. However, data obtained from these patients have yet to be analyzed in depth with respect to liver injury. METHODS The medical records of 136 patients who developed delayed-type drug hypersensitivity were reviewed at a tertiary referral hospital. Culprit drugs, the pattern and degree of...

Proton pump inhibitors are commonly used in clinical practice for the treatment of peptic ulcer and gastroesophageal reflux and are well tolerated by the patients. Their use is rarely associated with hypersensitivity and anaphylactic reactions. According to the reports in the Uppsala Monitoring Center database the frequency of hypersensitivity reactions out of all reported adverse reactions for...

Azathioprine hypersensitivity is a clinical syndrome which may manifest from isolated fever and rash to multi-organ failure. This rare condition is usually self-limiting following the discontinuation of azathioprine. Therefore, it is important to maintain a high index of clinical suspicion for hypersensitivity reactions with azathioprine therapy. We report a case of azathioprine hypersensitivit...

Lamotrigine is an antiepileptic drug widely used to control seizures. It has many adverse events but in rare instances, it can cause hypersensitivity syndrome (DHS). We describe a case of lamotrigine induced characterized by febrile erythema and eosinophilia. The suspect was replaced valproate leading marked improvement.

Anticonvulsant hypersensitivity syndrome is a systemic illness that presents most commonly as a triad of fever, rash, and lymphadenopathy in a patient exposed to one or more of the aromatic antiepileptic drugs (phenytoin, phenobarbital, and carbamazepine). Although generally self-limited, the syndrome may be life-threatening, particularly among patients who develop severe cutaneous eruptions or...

oral allergy syndrome (oas) is occasionally observed following consumption  of raw fruits  in  allergic adults. since this  phenomenon  was  commonly  reported  in  khorasan province of iran; we intended to check if common  diagnostic tests could be applied for differential diagnosis of oas to grapes. ige reactivity of 84 patients with oas to grape and 34 patients with oas to other fruits were ...

Dear Editor, Anticonvulsant hypersensitivity syndrome consists of the hallmark features of fever, rash, and lymphadenopathy and multiorgan involvement. We report a case of lamotrigine hypersensitivity that was diffi cult to diagnose because of comorbid systemic lupus eythrmatosus (SLE), and the presence of clinical features mimicking sepsis due to a zoonosis. The syndrome resolved with the disc...