Affecting approximately one in every 500 people, hypertrophic cardiomyopathy is a unique disease in which there is an abnormal increase in the thickness of the heart muscle. Although the cause of hypertrophic cardiomyopathy was unknown in the past, it is now recognized that people with hypertrophic cardiomyopathy have a gene mutation that causes this abnormality. Most people with hypertrophic c...

BACKGROUND Hypertrophic cardiomyopathy, a familial myocardial condition caused by sarcomere protein mutations, is usually recognized by early adulthood. Hypertrophic cardiomyopathy of the elderly has similar clinical features but, notably, a later age of onset and noncontributory family history. Causes of elderly-onset hypertrophic cardiomyopathy are unknown. METHODS AND RESULTS Eighteen wome...

Hypertrophic cardiomyopathy is an autosomal dominant inherited disease characterized by ventricular hypertrophy and myofibril disarray. Mutations responsible for hypertrophic cardiomyopathy have been identified in 11 genes that encode for cardiac sarcomere proteins. Traditionally, hypertrophic cardiomyopathy due to mutation of the myosin-binding protein C gene (MYBPC3) has been thought to follo...

Apical hypertrophic cardiomyopathy is an uncommon variant of non-obstructive hypertrophic cardiomyopathy with low prevalence outside East Asia. A case is reported of a non-Asian (European) 51 year old man with characteristic ECG and morphological changes of apical hypertrophic cardiomyopathy. Although the patient underwent catheterisation three years previously because of suggested coronary isc...

The topography and specificity of fibre disarray and fibrosis in hypertrophic obstructive cardiomyopathy were determined in a histological study comprising 40 necropsy hearts--10 with hypertrophic cardiomyopathy, 10 with congestive cardiomyopathy, 10 with aortic valve stenosis, and 10 normal hearts. Seven standard regional sections were sampled from each heart and graded "double-blind" (tissue ...

1. Sigwart U. Non-surgical myocardial reduction for hypertrophic obstructive cardiomyopathy. Lancet 1995;346:211–214. 2. Lakkis N, Nagueh SF, Kleiman NS, Killip D, He ZX, Verani MS, Roberts R, Spencer WH III. Echocardiography-guided ethanol septal ablation for hypertrophic obstructive cardiomyopathy. Circulation 1998;98: 1750–1755. 3. Knight C. Alcohol septal ablation for obstructive hypertroph...

An active, healthy, and symptom free 16 year old boy with a family history of hypertrophic cardiomyopathy died suddenly while walking home from school. Necropsy showed absence of left ventricular hypertrophy (that is, normal heart weight), though the characteristic histological abnormalities of hypertrophic cardiomyopathy, such as cardiac muscle cell disorganisation and abnormal intramural coro...

In 1957, Brock 1 described 3 patients with hypertrophic cardiomyopathy of which one of these patients had previously been hypertensive. Brock postulated that obstruction of the left ventricle outflow tract was caused by concentric hypertrophy of the subvalvular region of the left ventricle, which in turn resulted in sustained systemic hypertension. Later in 1970, Hambly 2 reported 8 cases of hy...

OBJECTIVE To estimate the total number of patients with idiopathic cardiomyopathy in Japan and the prevalence of the disorder. DESIGN A nationwide epidemiological survey. SETTING Hospitals selected randomly from among all hospitals in Japan. PATIENTS Patients presenting with any of the three types of idiopathic cardiomyopathy: dilated cardiomyopathy, hypertrophic cardiomyopathy, and restr...

Hypertrophy From Apical Hypertrophic Cardiomyopathy To the Editor: We read with interest the article by Reddy et al1 regarding a case with apical hypertrophic cardiomyopathy. The authors said that the 2D echocardiograph obtained from this patient indicated hypertrophy of the apex and that 201-Tl scintigraphic imaging demonstrated an increased count in the apical segment. However, because there ...