The objective of the present study was to monitor the hypolipidemic and hypocholesterolemic effects of propolis in rats fed high cholesterol diet. The rats (n=32) were divided into four equal groups. The rats of group 1 (control) were fed basal diet, whereas rats of group 2 were fed basal diet mixed with cholesterol (1%). The rats of group 3 and 4 were fed high cholesterol diet (1%) mixed with ...

In this paper, the nutritional quality of cheese samples and analogues was assessed throughout fatty acid profile lipid indices. The research included in which milk fat completely replaced by vegetable with addition palm coconut oil, as well mixed products, whose production based on use protein cheese. Fatty analysed gas chromatography-mass spectrometry (GC-MS), while atherogenic index, thrombo...

Herein we report on the multicomponent synthesis of a novel imidazole-based compound, able to act efficiently as a minimalist β-strand mimic. Biological evaluation proved its ability to impair the LDLR-PCSK9 protein-protein interaction, disclosing it as the first small molecule exerting a PCSK9-mediated hypocholesterolemic effect.

Hypercholesterolemia, low HDL-C and oxygen radicals have been implicated in the development of atherosclerosis. Lignan complex isolated from Flaxseed (Linum usitatissimum Linn., Linseed, Hindi ⎯ Alsi) contains secoisolariciresinol diglucoside (SDG), 3-hydroxy-3-methylglutaric acid (HMGA) and cinnamic acids. SDG and cinnamic acids are antioxidants and HMGA is a hypocholesterolemic agent. Antioxi...

Pakistan is rich in medicinally important plants and has ancient herbal treatment methods. Present work is based on the study of six indigenous plants Eugenia jambolana, Lawsonia inermis, Momordica charantia, Morus Corresponding author: Tel.: +92-21-4610132; E-mail [email protected] M. Saeed Arayne et al. Pak. J. Pharm. Sci., 2007, Vol.20(4), 268-273 269 alba, Nigella sativa and Trigonella foe...

Atherosclerosis is the primary cause of coronary heart disease. Markedly lowering blood cholesterol can halt and even reverse to some extent the progression of atherosclerosis. For these reasons, prevention should be the goal, with the focus on decreasing elevated blood cholesterol. About 20% of Americans between 20 and 75 years of age have blood total cholesterol levels above 240 mg/dL, a leve...