Trans-activator of transcription (Tat) is a cell penetrating peptide which can translocate and carry macromolecular cargoes through cell membranes. This study investigated the hypoglycemic activity of orally delivered insulin - Tat mixture in alloxan-induced diabetic mice. The mixtures of insulin and Tat at 1:1, 1:3 and 1:6 molar ratios were given orally at the insulin doses ranging from 1-200 ...

Three to six hours after the administration of extracts of neem bark or flower, the blood glucose levels of normal and streptozotocin-induced diabetic mice dropped significantly. However, neem flower possesses stronger hypoglycemic activity than the bark. Hypoglycemic action of these extracts may be due to their metabolic effect on tissue and or due to increase in insulin secretion.

The effect of severe insulin-induced hypoglycemia on the activity of the pyruvate dehydrogenase enzyme complex (PDHC) was investigated in homogenates of frozen rat cerebral cortex during burst suppression EEG, after 10, 30, and 60 min of isoelectric EEG, and after 30 and 180 min and 24 h of recovery following 30 min of hypoglycemic coma. Changes in PDHC activity were correlated to levels of lab...

The application of electroacupuncture (EA) to specific acupoints can induce a hypoglycemic effect in streptozotocin-induced rats, normal rats, and rats with steroid-induced insulin resistance. EA combined with the oral insulin sensitizer rosiglitazone improved insulin sensitivity in rats and humans with type II diabetes mellitus (DM). There are different hypoglycemic mechanisms between Zhongwan...

The aim of present review is to establish the use of plants, plant parts or extract in curing Diabetes mellitus. It also collates available data on plants with hypoglycemic effects. In the present investigation, interest is focused on experimental studies performed on hypoglycemic plants and their bioactive components. A brief description is given about the, type of diabetes, related physiologi...

background: the prevalence of type 2 diabetes is increasing in malaysia, with most patients poorly controlled. hence, this study aimed to determine nutritional and metabolic status as well as blood pressure of malaysian patients with type 2 diabetes mellitus and identify associated risk factors for poor glycemic control. materials and methods: a total of 104 type 2 diabetic patients were recrui...

Based on the data about structure and antidiabetic activity of twenty seven vanadium and zinc coordination complexes collected from literature we developed QSAR models using the GUSAR program. These QSAR models were applied to 10 novel vanadium coordination complexes designed in silico in order to predict their hypoglycemic action. The five most promising substances with predicted potent hypogl...

background: herbal medicine has been used for many years by different cultures around the world for the treatment of diabetes. objective: the hypoglycemic effect of caraway ethanolic extract (carum carvi l.) was investigated in normal and streptozotocin-induced diabetic rats. methods: intraperitoneal administration of caraway ethanolic extract seeds (0.1, 0.2, 0.4 and 0.6 g/kg body wt.) on the ...

OBJECTIVE Diabetes mellitus (DM) is associated with significant morbidity and mortality and its prevalence is increasing worldwide. Although conventional antidiabetic agents are known to ameliorate the symptoms of diabetes, they also may cause adverse effects. The purpose of this review was to organize and discuss various studies that have been previously conducted indicating the efficacy of Al...