A patient with idiopathic hypogonadotropic hypogonadism (IHH) had an apparently balanced reciprocal translocation involving chromosomes 13 and 16 [t(13;16)(q14.11;q24)]. The patient's father has the same chromosomal translocation with no apparent physical abnormalities. The role of the chromosomal translocation in this patient is discussed.

Prasad's syndrome is characterized by geophagia, growth retardation, hypogonadism, and zinc deficiency. We report a 15-year-old boy whose medical history and clinical and laboratory findings were fully compatible with Prasad's syndrome. In addition to severe growth retardation and pubertal delay, iron deficiency anemia and zinc deficiency were determined. His gliadin and endomysium antibodies w...

INTRODUCTION Arhinia, congenital absence of the nose, is a rare malformation. We present the third reported case of arhinia accompanied by hypogonadism and demonstrate that this is due to gonadotropin deficiency. CASE PRESENTATION A 13-year-old Caucasian boy with congenital arhinia presented for evaluation of delayed puberty and micropenis. We examined genes known to be associated with hypogo...

There is an increased risk of development of carcinoma of the breast in males with hypogonadism due to Klinefelter's syndrome. A patient with isolated hypogonadotropic hypogonadism and gynaecomastia developed an intraduct carcinoma of the breast. This is believed to be the first reported case of this association.

INTRODUCTION REPRODUCTIVE PHYSIOLOGY ANTERIOR PITUITARY TESTES FEEDBACK CONTROL OF GONADOTROPINS PROLACTIN AND GONADOTROPINS ANDROGEN PHYSIOLOGY HORMONAL CONTROL OF SPERMATOGENESIS DIAGNOSING ENDOCRINE ABNORMALITIES: CLINICAL FINDINGS SEMEN ANALYSIS BASELINE HORMONE EVALUATION DYNAMIC HORMONAL TESTING CLASSIFICATION OF ENDOCRINE CAUSES OF INFERTILITY PRIMARY HYPOGONADISM SECONDARY HYPOGONADISM ...

Mutations in the orphan nuclear receptor DAX-1 cause X-linked adrenal hypoplasia congenita. Affected boys usually present with primary adrenal failure in early infancy or childhood. Impaired sexual development because of hypogonadotropic hypogonadism becomes apparent at the time of puberty. We report adult-onset adrenal hypoplasia congenita in a patient who presented with hypogonadism at 28 yr ...

Despite recent advances in iron chelation therapy, excess iron deposition in pituitary gonadotropic cells remains one of the major problems in thalassemic patients. Hypogonadism, mostly hypogonadotropic hypogonadism, is usually detected during puberty. Early diagnosis and treatment are crucial for normal pubertal development and to reduce the complications of hypogonadism. The risks and benefit...

INTRODUCTION REPRODUCTIVE PHYSIOLOGY ANTERIOR PITUITARY TESTES FEEDBACK CONTROL OF GONADOTROPINS PROLACTIN AND GONADOTROPINS ANDROGEN PHYSIOLOGY HORMONAL CONTROL OF SPERMATOGENESIS DIAGNOSING ENDOCRINE ABNORMALITIES: CLINICAL FINDINGS SEMEN ANALYSIS BASELINE HORMONE EVALUATION DYNAMIC HORMONAL TESTING CLASSIFICATION OF ENDOCRINE CAUSES OF INFERTILITY PRIMARY HYPOGONADISM SECONDARY HYPOGONADISM ...

INTRODUCTION REPRODUCTIVE PHYSIOLOGY ANTERIOR PITUITARY TESTES FEEDBACK CONTROL OF GONADOTROPINS PROLACTIN AND GONADOTROPINS ANDROGEN PHYSIOLOGY HORMONAL CONTROL OF SPERMATOGENESIS DIAGNOSING ENDOCRINE ABNORMALITIES: CLINICAL FINDINGS SEMEN ANALYSIS BASELINE HORMONE EVALUATION DYNAMIC HORMONAL TESTING CLASSIFICATION OF ENDOCRINE CAUSES OF INFERTILITY PRIMARY HYPOGONADISM SECONDARY HYPOGONADISM ...

INTRODUCTION REPRODUCTIVE PHYSIOLOGY ANTERIOR PITUITARY TESTES FEEDBACK CONTROL OF GONADOTROPINS PROLACTIN AND GONADOTROPINS ANDROGEN PHYSIOLOGY HORMONAL CONTROL OF SPERMATOGENESIS DIAGNOSING ENDOCRINE ABNORMALITIES: CLINICAL FINDINGS SEMEN ANALYSIS BASELINE HORMONE EVALUATION DYNAMIC HORMONAL TESTING CLASSIFICATION OF ENDOCRINE CAUSES OF INFERTILITY PRIMARY HYPOGONADISM SECONDARY HYPOGONADISM ...