Case presentation: Young male, 17 years old, born in Rio de Janeiro, with a history of global developmental delay and neuroimaging leukoencephalopathy. Basic screening for inborn errors metabolism, ophthalmoscopy electroneuromyography did not show any changes. Specific enzyme measurements performed during diagnostic investigation excluded leukodystrophies Tay-Sachs as possible etiologies. The p...

SUMMARY: We investigated the brain magnetic susceptibility changes induced by natalizumab-associated progressive multifocal leukoencephalopathy. We retrospectively included 12 patients with natalizumab–progressive multifocal leukoencephalopathy, 5 with progressivemultifocal leukoencephalopathy fromother causes, and 55 patients withMSwithout progressivemultifocal leukoencephalopathy for comparis...

OBJECTIVE To describe a patient with reversible posterior leukoencephalopathy syndrome following the administration of bevacizumab (Avastin), a monoclonal antibody against vascular endothelial growth factor. DESIGN Case report/literature review. SETTING University hospital. PATIENT A 52-year-old man receiving chemotherapy for stage IV rectal carcinoma. RESULTS Clinical and radiographic ...

BACKGROUND Systemic lymphoma can be difficult to recognize due to its diverse manifestations. Paraneoplastic leukoencephalopathy has rarely been reported in the context of lymphoma. CASE REPORT We report a 45-year-old man with systemic lymphoma whose initial manifestation was sudden-onset leukoencephalopathy, mimicking stroke. This patient, who was eventually diagnosed with diffuse large B-ce...

In this paper we construct new examples of minimal Lagrangian submanifolds in the complex hyperbolic space with large symmetry groups, obtaining three 1-parameter families with cohomogeneity one. We characterize them as the only minimal Lagrangian submanifolds in CHn foliated by umbilical hypersurfaces of Lagrangian subspaces RHn of CHn. Several suitable generalizations of the above constructio...

levamisole is an anthelmintic agent and also immunostimulant drug which is used to treat colorectal cancer. the present study aimed to show accidental consumption of levamisole alone induced multifocal inflammatory leukoencephalopathy. a 53-year-old male was admitted to the neurology department of farabi hospital (kermanshah, iran) with walking inability and recognition disorder. following clin...

Toxic leukoencephalopathy results from damage to the white matter caused by various toxins. It manifests itself as white matter signal abnormalities with or without the presence of restricted diffusion. These changes are often reversible if the insulting agent is removed early, with the exception of posthypoxic leukoencephalopathy that can manifest itself 1-2 weeks after the initial insult. How...

Twelve patients with brain tumors and progressive edema caused by tumor progression or radiochemotherapy-related leukoencephalopathy were treated with H15, a phytotherapeutic anti-inflammatory agent. Edema was reduced in two of seven patients with glioblastoma with tumor progression and in three of five patients with treatment-related leukoencephalopathy. All patients with leukoencephalopathy i...