We encountered 2 cases of hypophosphatemia due to Legionella pneumonia. Both cases showed increased urinary phosphate excretion and renal tubular dysfunction, which ameliorated with recovery from Legionella pneumonia. Serum fibroblast growth factor-23 level was suppressed, whereas serum 1,25(OH)2 vitamin D and parathyroid hormone levels were normal. Delayed elevation of serum 1,25(OH)2 vitamin ...

Background and Objectives. Hypoparathyroidism in patients with functioning kidneys leads to hyperphosphatemia. This article reviews data suggesting that hypoparathyroidism in patients on dialysis leads to hypophosphatemia. Design. Clinical data of the following were reviewed: (a) a patient with hypoparathyroidism before and during chronic dialysis; (b) patients on dialysis with surgically creat...

The fate of an intravenous dose of tritiated vitamin D(3) was studied in seven normal subjects, four children with vitamin D-resistant rickets, and four adults with a familial history of vitamin D-resistant rickets and persistent hypophosphatemia. An abnormal metabolism of vitamin D in vitamin D-resistant rickets was defined and characterized by a decrease in the plasma fractional turnover rate...

An X-linked dominant mutation (gyro, gene symbol Gy) in the laboratory mouse causes hypophosphatemia, rickets/osteomalacia, circling behavior, inner ear abnormalities, and sterility in males and a milder phenotype in females. Gy maps closely (crossover value 0.4-0.8%) to another X-linked gene (Hyp) that also causes hypophosphatemia in the mouse. Gy and Hyp genes have similar quantitative expres...

Hypophosphatemia is a relatively uncommon finding in clinical practice, with a prevalence of 1–5% in all hospitalized patients. However, it is an adverse prognostic marker for mortality and morbidity. Although the correlation between serum phosphate levels and symptoms is not linear, severe hypophosphatemia is important to recognize and treat since it can lead to rhabdomyolysis, haemolysis, res...

Phosphorus is a key component of bone, and a deficiency results in poor mineralization along with other systemic symptoms of hypophosphatemia. Various causes of hypophosphatemia with renal wasting of phosphorus have been identified. These include the Fanconi syndrome, various genetic mutations of fibroblast growth factor 23 (FGF23) handling and the sodium/phosphate cotransporter, and those due ...

backgroundrickets is a disorder due to impaired metabolism of bone mineralization which caused by low concentrations of extra-cellular calcium or phosphate. in children, hypophosphatemic rickets (hr) happen malabsorption of phosphate and increasing of renal tubular loss.case presentation we present the case of a 4-year-old girl who had medical history of hr with failure to thrive (ftt). child h...

Cannabinoid hyperemesis syndrome (CHS) involves cyclical nausea, vomiting, and abdominal pain linked to use of cannabis with resolution symptoms upon cessation cannabinoids. Although electrolyte disturbances, fluid imbalances, nutritional deficiencies are known complications CHS in the setting intractable severe hypophosphatemia is a rare clinical phenomenon cited primarily adult literature. Pe...