Down syndrome (DS) is the most common genetic cause of mental retardation. It is estimated that 5-13% of persons affected by DS have seizures. Infantile spasms are the most common type of seizures and usually are well controlled with steroids and antiepileptic drugs. We present 11 children at the age of 3 years and 4 months to 10 years and 7 months with DS and infantile spasms, treated at Child...

PEHO syndrome is a rare symptom complex of severe progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy. Disease onset is in early infancy. The current case report presents and discusses serial conventional MR imaging findings and serial functional studies including diffusion tensor imaging and quantitative MR spectroscopy findings in a 6-year-old child with PEHO.

Background: Treatment of infantile spasms (ISs) with allopathic medicines along homeopathy is poorly understood in context the seizure profile, psychomotor outcome, and electroencephalogram (EEG) changes. Objectives: The objective study was to evaluate role homeopathic treatment control, development, EEG changes patients IS. Materials Methods: An open label, single-arm, clinical trial conducted...

A 4-month-old girl presented with myoclonic seizures and an electroencephalogram showing hypsarrhythmia. Hyperglycinuria and a cerebrospinal fluid to plasma glycine ratio of 0.2 suggested the diagnosis of non-ketotic hyperglycinaemia. Propionic acid and methyl citric acid were present in the urine, and propionyl coenzyme A carboxylase was deficient in leucocytes and fibroblasts. The ketotic and...

Background: West syndrome (WS) is an epileptic encephalopathy characterized by spasms, neurodevelopment delay, and hypsarrhythmia on electroencephalography. Infantile spasms have incidence of about 0.43 per 1000 livebirths occur between 3 12 months age. The drug's choice the adrenocorticotrophic hormone (ACTH), with varied response rates limited efficacy data, relapses, evolution to other kinds...