PURPOSE The objective of this study was to determine the feasibility of exploiting the overexpression of somatostatin subtype-2 receptors (sstr(2)) on human medulloblastoma cells to develop targeted radiodiagnostics and radiotherapeutics for this disease. EXPERIMENTAL DESIGN The following radioiodinated peptides were prepared using chloramine-T and evaluated: [(131)I-Tyr(3)]octreotide ([(131)...

objective: glioblastoma multiforme (gbm), one of the most common and aggressive malignant brain tumors, is highly resistant to radiotherapy. numerous approaches have been pursued to find new radiosensitizers. we used a picogreen and colonogenic assay to appraise the dna damage and cell death in a spheroid culture of gbm cells caused by iodine-131 (i-131) beta radiation in the presence of topote...

OBJECTIVE The current study aimed to determine the efficacy of radioiodine-131 ((131)I) ablation therapy with thyroid hormone replacement one day before (131)I administration in patients with well-differentiated thyroid cancer (DTC). METHODS This retrospective study included 29 patients who underwent (131)I therapies twice for DTC during 6-12 months. Since all the patients obviously had resid...

A retrospective study of radiolodine therapy for thyrotoxicosis was done in 402 patients over a period of 10 years from 1963 to 1972. The patients were classified as follows: (1) Age (2) Sex (3) Size of the gland estimated by physical exmination (4) Type of goitre (diffuse, nodular) (5) Ocular signs (6) Number of doses and (7) Total dose of 1-13 1 administered. The usual age for the treatment w...

The irradiation of a thorium target by light charged particles (protons and deuterons) leads to the production of several isotopes of medical interest. Direct nuclear reaction allows the production of Protactinium-230 which decays to Uranium-230 the mother nucleus of Thorium-226, a promising isotope for alpha radionuclide therapy. The fission of Thorium-232 produces fragments of interest like M...

RADIOACTIVE iodine (iodine-131) has been used extensively during the past 30 years for the treatment of hyperthyroidism and has been shown to control this disorder in the majority of cases in which it has been used. There have been varying reports of the incidence of post-radiation hypothyroidism which has been reported to be as high as 70 per cent in patients followed up for 10 years (Beling a...

Introduction:The post-surgical management of patients with differentiated thyroid cancer include ablation of remnant local and distant metastatic tissues with 131I therapy, which accentuates isolation of the patient in order to avoid unnecessary radiation exposure to the care givers, general public and the environment. The duration of isolation is subject to the redu...