speech delay with an unknown cause is a problem among children. this diagnosis is the last differential diagnosis after observing normal findings in routine hearing tests. the present study was undertaken to determine whether auditory brainstem responses to click stimuli are different between normally developing children and children suffering from delayed speech with unknown causes. in this cr...

In mice, plasmacytoid dendritic cells (pDC) and natural killer (NK) cells both contribute to resistance to systemic infections with herpes viruses including mouse Cytomegalovirus (MCMV). pDCs are the major source of type I IFN (IFN-I) during MCMV infection. This response requires pDC-intrinsic MyD88-dependent signaling by Toll-Like Receptors 7 and 9. Provided that they express appropriate recog...

This paper studies the notions of conceptual grounding and explanation (which includes notion mathematical explanation), with an aim clarifying links between them. On one hand, it analyses complex examples these two that bring to fore features are easily overlooked otherwise. other provides a formal framework for modeling both explanation, based on concept proof. Inspiration analogies drawn rec...

Hepatitis C virus (HCV) is responsible for a vast majority of liver failure cases. HCV is a kind of blood disease appraised to chronically infect 3% of the worlds’ population causing significant morbidity and mortality. Therefore, a complete knowledge of humoral responses against HCV, resulting antibodies, and virus-receptor and virus-antibody interactions, are essential to design a vaccine. HC...

Events in a sequence may each be evaluated as good or bad. We propose that such good-bad evaluations evoke emotional responses that change current mood. A model of recurrent updating of current mood is developed and compared to a model of how a sequence of events evoking emotional responses is evaluated retrospectively. In Experiment 1, 149 undergraduates are presented sequences of lottery outc...

Distortion product otoacoustic emission (DPOAE) growth functions reflect the active nonlinear cochlear sound processing when using a primary-tone setting which accounts for the different compressions of the two primaries at the DPOAE generation site and hence provide a measure for objectively assessing cochlear sensitivity and compression. DPOAE thresholds can be derived from extrapolated DPOAE...

the misconception (shubha) of absolute nonexistent – which we have named as paradox – is not an amusing brainteaser; rather, it is one the significant epistemological issues. its importance can be looked upon from two different viewpoints: research and educational. it is significant from the research viewpoint because it challenges propositions which constitute the foundation of our thinking an...

there are many real problems in which multiple responses should be optimized simultaneously by setting of process variables. one of the common approaches for optimization of multi-response problems is desirability function. in most real cases, there is a correlation structure between responses so ignoring the correlation may lead to mistake results. hence, in this paper a robust approach based ...