OBJECTIVE The clinical use of Transcranial Magnetic Stimulation (TMS) as a technique to assess corticospinal excitability is limited by the time for data acquisition and the measurement variability. This study aimed at evaluating the reliability of Stimulus-Response (SR) curves acquired with a recently proposed rapid protocol on tibialis anterior muscle of healthy older adults. METHODS Twenty...

Ketoconazole is an imidazole oral antifungal agent with a broad spectrum of activity. Ketoconazole has been reported to cause liver damage, but the mechanism is unknown. However, ketoconazole and a related rug, miconazole, have been shown to have inhibitory effects on oxidative phosphorylation in fungi. Fluconazole, another orally administered antifungal azole, has also been reported to cause l...

Neuropathy target esterase (NTE) is the target protein for neuropathic organophosphorus (OP) compounds that produce OP compound-induced delayed neurotoxicity (OPIDN). Inhibition/aging of brain NTE within hours of exposure predicts the potential for development of OPIDN in susceptible animal models. Lymphocyte NTE has also found limited use as a biomarker of human exposure to neuropathic OP comp...

The inhibitory effects of miconazole, an antimycotic agent, on aromatase activity for androstenedione in human placenta (105,000 X g pellet fraction) and ovary (800 X g supernatant fraction) were investigated. Various concentrations (0.1-100 microM) of miconazole, aminoglutethimide or delta 1-testololactone were added to the human placental preparation (1 mg protein) and then the mixture was in...

Reversible nonphotochemical fluorescence quenching depends on thylakoid lumen acidification and violaxanthin de-epoxidation and is correlated with photoprotection of photosynthesis. The O2-dependent electron flow in the coupled Mehler-ascorbate peroxidase reaction (MP-reaction) mediates the electron flow necessary for lumen acidification and violaxanthin de-epoxidation in isolated, intact chlor...

This paper reports the first C. radiata population with resistance to glyphosate and multiple acetolactate synthase (ALS) inhibitor, imazamox. Two populations, one putative resistant (R) susceptible (S), were used in studies. Dose–response experiments performed evaluate factor (RF). Shikimic acid accumulation, 5-enolpyruvylshikimate-3-phosphate (EPSPS) ALS enzyme activities studied together che...

Oil content and fatty acid composition are the most significant quality criteria of peanuts (Arachis hypogaea L.), these parameters is greatly influenced by irrigation fertilization practices. A study was conducted to investigate effects intervals levels on oil peanuts, under sandy soil conditions in two consecutive years, using ‘Halisbey’, ‘NC-7’, ‘Sultan’ peanut cultivars, commonly grown Turk...

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Malonyl-CoA inhibition of carnitine palmitoyltransferase I was found to be very pH-dependent. Malonyl-CoA concentrations causing 50% inhibition (I50) at pH 6.0, 6.5, 7.0, 7.5 and 8.0 were 0.04, 1, 9, 40 and 200 microM respectively. It is suggested that a lowering of intracellular pH, such as might occur in ketoacidosis, may attenuate hepatic fatty acid oxidation by increasing malonyl-CoA sensit...

Chitosan coated iron nanoparticles were synthesized by co-precipitation method and also Nanoparticles evaluate the effect of surface coating on stability toxicity nanoparticles. FTIR amino groups acted as a capping site for Iron stabilization. Invitro cytotoxicity is dependent dose-based their reduction was observed in SKMEL cancer cells administered with different concentration samples. I50 va...