Intercellular adhesion molecule-1 (ICAM-1) is expressed on vascular endothelial cells and its expression increases during the inflammatory response in patients with active Behcet's disease (BD). The ICAM1 gene mutations are associated with BD in Caucasians, but clinical features of the mutation phenotype are unknown. We analyzed ICAM1 polymorphisms in Korean BD patients to determine if there wa...

OBJECTIVE To find out host gene expression profiles after malarial infection. METHODS Further time-course microarray analysis of peripheral blood mononuclear cells focusing on malaria pathogenesis was performed. RESULTS Up-regulation of coagulation-related genes, heat shock proteins, glycolytic enzymes, glucose transporters, and vacuolar H(+)-ATPases was found in acute febrile malaria. In e...

To investigate the association of sICAM-1 and sVCAM-1 with ICAM1 721G>A and VCAM1 1238G>C polymorphisms and rheumatoid arthritis (RA) clinical activity, sixty RA patients and 60 healthy non-related subjects (HS) matched for age and sex were recruited. Soluble adhesion molecules were determined by ELISA technique. Rheumatoid factor (RF), C reactive protein (CRP) and the erythrocyte sedimentation...

Fragments of intercellular adhesion molecule 1 (ICAM- 1) containing only the two most N terminal of its five immunoglobulin SF domains bind to rhinovirus 3 with the same affinity and kinetics as a fragment with the entire extracellular domain. The fully active two-domain fragments contain 5 or 14 more residues than a previously described fragment that is only partially active. Comparison of X-r...

The purpose of this investigation was to examine mutations and mRNA levels potential genes linked diarrhea susceptibility in order assess the health status diarrheic kids Baladi goats. One hundred female (35 65 apparently healthy) were used. PCR-DNA sequencing conducted for TMED1, CALR, FBXW9, HS6ST3, SMURF1, KPNA7, FBXL2, PIN1, S1PR5, ICAM1, EDN1, MAPK11, CSF1R, LRRK1, CFH markers revealed nuc...

The tumor microenvironment is generally hypoxic because of the limited oxygen supply from inefficient or insufficient vasculature. Hypoxic tumor tissues are also poorly supplied with serum components. We have previously demonstrated that expression of the FVII gene is induced in response to hypoxia in ovarian clear cell carcinoma (CCC) cells. This gene activation is synergistically enhanced whe...

The contribution of polymorphic markers rs2234663 (VNTR) and rs419598 (c.2008T>C) the IL1RN gene to predisposition development arterial hypertension among population Karelia was studied. occurrence alleles genotypes for these almost same in group healthy people patients with (χ2 = 0.178, p 0.67; χ2 0.540, 0.76; 0.01, 0.93, 1.68, 0.43, respectively rs419598). level IL-1β IL-1α plasma did not ...

Retinal damage is an optional sign in a number of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). The aim this work was to assess the structural and functional state retina murine model ALS caused by overexpression aberrant FUS protein [1-359]. retinal examination carried out on 12 transgenic 13 wild-type mice 2.5–3 months age. study revealed not statistically signifi...