We reported a rare case of hypothalamic amenorrhea and transverse vaginal septum. A 28-year-old woman presented with primary amenorrhea and no complaint of abdominal pain. Laparoscopy revealed a small rudimentary uterus with streak ovaries and a vaginal pouch. The patient with diagnosis of Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome was subjected to a vaginoplasty in another fertility center...

Most adolescent gynecological problems are related to sexual activity or the development or failure of hypothalamic-pituitary-ovarian-uterine activity. The 1st years of menstruation are usually anovulatory resulting in variable periods of amenorrhea which corrects itself in time. In profuse menstrual loss, endocrine, metabolic, and hemorrhagic disorders must be exlcuded before treatment with p...

Functional disorders of the hypothalamus are the most common reason for amenorrhea. Psychogenic stress, undernutrition and excessive exercise are frequently associated with functional hypothalamic amenorrhea (FHA). It is a nonorganic endocrine disorder characterized by the impairment of gonadotropin-releasing hormone (GnRH) pulsatile secretion. The incidence of FHA ranges from 15% to 55% of the...

BACKGROUND Primary ovarian insufficiency (POI) is characterized by 4 to 6 months of amenorrhea and elevated serum FSH and LH in females less than 40 years. Ovarian insufficiency is uncommon in pediatrics and typically results from a chromosomal abnormality or treatment for malignancy. Idiopathic POI in which no apparent precipitant is identified is even rarer. After encountering three teens wit...

This review aims at defining the neuroendocrine mechanisms underlying sport-induced restrictions of reproductive axis in female athletes. Episodic gonadotropin release was found to be compromised, presumably a result impaired hypothalamic pulsatile GnRH release. Any deviation from optimal may suboptimal function ovaries, leading disorders menstrual cycle and ovulation. A whole spectrum dysfunct...

OBJECTIVE To investigate whether allopregnanolone, a neuroactive steroid involved in modulating behavioural and neuroendocrine functions, shows episodic secretion in eumenorrheic women, during the follicular and luteal phases of the menstrual cycle, and in women with stress-induced amenorrhea. PATIENTS Six eumenorrheic women and 14 women with hypothalamic amenorrhea were enrolled for the pres...