Abstract Acromegaly is a rare, chronic disease that is, in more than 95% of cases, caused by growth hormone (GH)-secreting pituitary adenoma. Overproduction insulin-like factor-1 (IGF-1) due to GH hypersecretion leads various clinical features characterized somatic overgrowth, physical changes, multiple comorbidities, and increased mortality. The average age at diagnosis 40 50 years, with no se...

Background & Objective: To find an association between gene variants of insulin-like growth factor-1 (IGF-1) and 5,10-methylenetetrahydrofolate reductase (MTHFR) with the risk of acne vulgaris (AV). Methods: In a case-control study, we investigated 150 AV patients and 148 healthy individuals (aged 18-25 years) for the IGF-1 G>A and MTHFR C677T polymorphis...

Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are the most important regulators of growth, regeneration metabolism. The influence GH IGF-1 on pediatric liver transplant outcomes is mediated through body weight regulation, specific effects hepatocyte function immune system activity. In recent years, blood levels these factors life expectancy, both in healthy individuals recipients...

introduction  insulin-like growth factor i (igf-i) which is produced in abundance in the normal adult liver, is deeply involved in hepatocyte survival, growth, and differentiation during liver development. igf-i plays the roles via the receptor (igf-ir) signaling pathway. igf-ir unlike igf-i is expressed strongly in the developing liver, but much more weakly in adults. objective:  we hypothesiz...

There is increasing evidence to indicate that insulin‑like growth factor (IGF)‑1 plays a crucial role in the regeneration of different tissues following injury. Notably, despite escalating number animal studies, studies investigating IGF‑1 wound healing process humans are fewer. In this context, aim present study was evaluate variations expression isoforms (IGF1‑Ea, IGF1‑Eb and IGF1‑Ec), as wel...

Background: Morphine is wildly used as a painkiller in clinics, but causes several side effects such as hyperalgesia, depression and more notably amnesia. Here, we assumed that insulin-like Growth Factor-1 (IGF-1) as a peptide with widespread distribution of receptors in brain regions, especially hippocampus, might be capable to alleviate morphine-induced amnesia. Meth...