نتایج جستجو برای: igvh mutation
تعداد نتایج: 291497 فیلتر نتایج به سال:
Elevated levels of circulating angiogenic cytokines and increased expression of genes encoding angiogenic factors have been reported in recent years in patients with chronic lymphocytic leukemia (CLL) but data regarding prognostic and predictive significance are still limited. Therefore, in the present study based upon our prior pilot results, we measured mRNA expressions of angiopoietin-2 (Ang...
The results of repeated interphase fluorescence in-situ hybridization (I-FISH, FISH) examination of 97 CLL patients and correlation of these findings with IgVH hypermutation status, ZAP-70 and CD38 expression are presented. The appearance of new, FISH-detectable, genomic aberrations during disease course, described as clonal evolution (CE), was observed in 26% of patients. The most frequent new...
FISH studies on 37 ocular MALT-type lymphomas yielded chromosomal translocations affecting MAL andT1 BCL10 in 1 case each, no evidence for a break in the FOXP1 locus, and trisomy 3 in 14 out of 34 cases (41%). Three out of 8 cases analyzed used the highly mutated VH3-23 gene and showed ongoing somatic hypermutations.
Chronic lymphocytic leukemia (CLL) has an extremely heterogeneous prognosis. Nowadays, the median survival of patients with this form of leukemia is 8–10 years, compared with 5–6 years in series reported in the 1970s. This is largely due to the higher number of patients who are now being diagnosed in early phase (up to 80%) and, hence, with better prognosis [1, 2]. Individual survival, however,...
Introduction: The prognosis of chronic lymphocytic leukemia (CLL) varies widely individually. clinical staging systems by Rai and Binet, cytogenetics/FISH, mutational status IGHV have been commonly used as prognostic factors for CLL patients. advent molecular panels next-generation sequencing might provide additional markers to predict the outcome In this study, we evaluate gene mutation profil...
To date, there is no consensus regarding the influence of different CD45 isoforms during peripheral B-cell development. Examining correlations between surface CD45RO expression and various physiologic processes ongoing during the germinal center (GC) reaction, we hypothesized that GC B cells, like T cells, that up-regulate surface RO should progressively acquire phenotypes commonly associated w...
Pyrrolo-1,5-benzoxazepine-15 (PBOX-15) is a novel microtubule depolymerization agent that induces cell cycle arrest and subsequent apoptosis in a number of cancer cell lines. Chronic lymphocytic leukemia (CLL) is characterized by clonal expansion of predominately nonproliferating mature B cells. Here, we present data suggesting PBOX-15 is a potential therapeutic agent for CLL. We show activity ...
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