نتایج جستجو برای: il7r
تعداد نتایج: 206 فیلتر نتایج به سال:
Multiple sclerosis is a chronic neurological disease, where both genetic and environmental factors are influencing the susceptibility and pathogenesis. Epidemiological studies have clearly demonstrated the existence of a genetic component by comparing the degree of shared genetic material and the risk of MS, where the degree of shared genetic material clearly correlates with the risk of MS. Unt...
Gain-of-function mutations in interleukin-7 receptor-a (IL7R) in childhood acute lymphoblastic leukemias Chen Shochat, Noa Tal, Obul R. Bandapalli, Chiara Palmi, Ithamar Ganmore, Geertruy te Kronnie, Gunnar Cario, Giovanni Cazzaniga, Andreas E. Kulozik, Martin Stanulla, Martin Schrappe, Andrea Biondi, Giuseppe Basso, Dani Bercovich, Martina U. Muckenthaler, and Shai Izraeli Vol. 208, No. 5, May...
Recent studies of acute lymphoblastic leukemia have identified activating mutations in components of the interleukin-7 receptor complex (IL7R, JAK1, and JAK3). It will be of interest to investigate both JAK1 and JAK3 kinase inhibitors as targeted agents for these leukemias.
The Leiden Longevity Study consists of families that express extended survival across generations, decreased morbidity in middle-age, and beneficial metabolic profiles. To identify which pathways drive this complex phenotype of familial longevity and healthy aging, we performed a genome-wide gene expression study within this cohort to screen for mRNAs whose expression changes with age and assoc...
We aimed to explore the tumor mutational burden (TMB) and immune infiltration in HCC investigate new biomarkers for immunotherapy. Transcriptome gene mutation data were downloaded from GDC portal, including 374 samples 50 matched normal samples. Furthermore, we divided into high low TMB groups, analyzed differential genes between them with GO, KEGG, GSEA. Cibersort was used assess cell Finally,...
Systemic lupus erythematosus (SLE) is a female-biased multisystem inflammatory disease with substantial morbidity and mortality limited treatment options. Our lab previously found that VGLL3, putative transcription co-factor increased activity in female cells, can drive lupus-like systemic inflammation when overexpressed mouse epidermis under the K5 promoter. IL-7 signaling was to be elevated s...
BACKGROUND Allergic rhinitis (AR) affects up to 80% of children with asthma and increases asthma severity. Thymic stromal lymphopoietin (TSLP) is a key mediator of allergic inflammation. The role of the TSLP gene (TSLP) in the pathogenesis of AR has not been studied. OBJECTIVE To test for associations between variants in TSLP, TSLP-related genes, and AR in children with asthma. METHODS We g...
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