These comparative studies on the aggregation behaviour of Ac-(Z)-∆Abu-NMe2 and Ac-L-AbuNMe2 in carbon tetrachloride were performed by the analysis of their FTIR spectra and by theoretical calculations. The percentage of the monomeric form (α) decreased as concentration increased and this occurred to a higher degree for the (Z)-∆Abu derivative than for its saturated analogue. The dimerization co...

report on page 639 identifies a family of proteins that are important when worms are unable to deal with ER stress. The results from Urano et al. suggest that these proteins are receptors for incorrectly folded proteins at the ER. In worms and other eukaryotes, conditions that stress the ER, such as those that inhibit glycosylation, activate the unfolded protein response (UPR). The UPR comprise...

The severity of urinary tract infection (UTI) reflects the quality and magnitude of the host response. While strong local and systemic innate immune activation occurs in patients with acute pyelonephritis, the response to asymptomatic bacteriuria (ABU) is low. The immune response repertoire in ABU has not been characterized, due to the inherent problem to distinguish bacterial differences from ...

Escherichia coli is the most common organism associated with asymptomatic bacteriuria (ABU) in humans. In contrast to uropathogenic E. coli (UPEC) that cause symptomatic urinary tract infection, very little is known about the mechanisms by which these strains colonize the urinary tract. Here, we have investigated the biofilm-forming capacity on abiotic surfaces of groups of ABU strains and UPEC...

The endoplasmic reticulum stress response, also known as the unfolded protein response (UPR), has been implicated in the normal physiology of immune defense and in several disorders, including diabetes, cancer, and neurodegenerative disease. Here, we show that the apoptotic receptor CED-1 and a network of PQN/ABU proteins involved in a noncanonical UPR response are required for proper defense t...

A 61-year-old woman was seen with diastasis of the symphysis pubis and insufficiency fractures of the wings of both ilia after irradiation for carcinoma of the cervix. The characteristics and treatment of these fractures are discussed.

1.—Composite Materials and Mechanics Laboratory, Department of Mechanical and Aerospace Engineering, New York University Tandon School of Engineering, Brooklyn, NY 11201, USA. 2.—Department of Computer Science and Engineering, New York University Tandon School of Engineering, Brooklyn, NY 11201, USA. 3.—Engineering Division, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates. 4.—Dep...

A high degree of diversity noted in the Neolithic mandibles from Abu Hureyra provided the opportunity to address the problem of the meaning and origin of variability in the population. Mandible morphology is approached bearing in mind cranio-facial interactions. Two morphological patterns were identified in the Abu Hureyra mandible sample. e ABU morph represents the majority, while the ABO mor...