The search for greater sensitivity for detecting small subclinical tumor deposits and improved specificity for distinguishing between malignant and benign masses has led to the development of techniques for linking radioactive labels to tumor-specific antibodies or tissue-specific biochemical agents. Major progress is occurring as well in the development of nonspecific physiologic nuclear medic...

Inexpensive Limited sensitivity, particularly in dense breasts ULTRASOUND Targeted ultrasound very useful for palpable Widespread availability Limited specificity, particularly screening or mammographic findings Good sensitivity Very operator dependent Delineates cystic from solid, and many benign Inexpensive solid abnormalities from malignancies Screening ultrasound controversial due to low po...

We propose to enhance the axial resolution of photoacoustic microscopy (PAM) by reducing the speed of sound within the imaging region of interest. With silicone oil immersion, we have achieved a finest axial resolution of 5.8 μm for PAM, as validated by phantom experiments. The axial resolution was also enhanced in vivo when mouse ears injected with silicone oil were imaged. When tissue-compati...

Ultrasound has been a popular clinical imaging modality for decades. It is well established as a means of displaying the macroscopic anatomy of soft-tissue structures. While conventional ultrasound methodologies (i.e., B-mode and Doppler methods) are well proven and continue to advance technically on a daily basis, e.g. by extending into higher frequencies and taking advantage of harmonic pheno...