Absence of the cystic fibrosis transmembrane regulator (CFTR) function leads to chronic lung disease characterized by inflammation and persistent infections. The mechanisms for the increased susceptibility of the respiratory tract for infections in CF are most likely complex and only partially understood. Most attention has been focused on the effect of the defective expression of CFTR in epith...

Immune deficiency in cancer patients is well documented, and tumor cells have developed a variety of cellular and molecular mechanisms to avoid antitumor immune responses. These mechanisms include defective presentation of tumor antigens on the cell surface and/or an inability of the host to effectively recognize these cells and target them for destruction. Tumor-induced defects are known to oc...

The association between immunity and neurodevelopmental disorders has been extensively investigated in autism, suggesting a potential involvement of both cellular and humoral immunity in the establishment of synaptic connectivity modulation during development. A similar link has been proposed also for Tourette syndrome (TS), a complex, multifactorial disorder, in which the interplay between gen...

COVID-19, caused by the SARS-CoV-2 virus, has become pandemic. With sharply rising infection rates, patient groups characterized an enhanced risk will be challenged virus. In this context, patients with chronic immune-mediated inflammatory diseases are of particular interest, as these intrinsic immune dysfunction leading to inflammation that may enhance for severe infection.

Histoplasmosis is caused by the dimorphic fungus - Histoplasma capsulatum. The presentation of histoplasmosis often disseminated, though primary intestinal involvement can rarely be seen in patients with cell mediated immune dysfunction like AIDS. We report a case renal allograft recipient, who had history COVID 19 infection and also underwent anti-rejection treatment for graft dysfunction, pre...

Hereditary angioedema (HAE) is well documented condition with inherited deficiency or dysfunction of C1 inhibitor. However, its association other immune disorders such as autoimmunity, malignancy and primary immunodeficiency not known.

Long-term sun exposure markedly accelerates the skin changes of chronological aging, leading to deterioration function and appearance in a process termed Photoaging. The molecular mechanisms underlying photoaging remain incompletely defined, due largely limitations ex vivo studies. To interrogate this phenomenon vivo, we performed single-cell RNA-seq sun-protected sun-exposed from four ∼20-year...