BACKGROUND Patients receiving hematopoietic stem cell transplantation require extensive transfusion support until red blood cell and platelet engraftment occurs. Rare but predictable complications may arise when the transplanted stem cells are incompatible with the native ABO type of the patient. Immediate and delayed hemolysis is often seen. METHODS A literature review was performed and the ...

Differential Diagnosis of Hemolytic Anemia Hemolytic anemia reflects shortened RBC life span due to intravascular, extravascular, or fragmentation hemolysis. Intravascular hemolysis is primarily associated with type 1 hypersensitivity reactions, either idiopathic or secondary to another primary disease. In some cases an infectious intraerythrocytic or epierythrocytic agent or miscellaneous diso...

Evans syndrome (ES) is a rare autoimmune disorder whose exact pathophysiology is unknown. It is characterized by the simultaneous or subsequent development of autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Intravascular hemolysis, with hemoglobinemia, is known to produce acute kidney injury; however, the development of intratubular hemoglobin casts (hemoglobin cast nephro...

Background Autoimmune hemolytic anemia is a hematologic disorder that is rarely observed in infants and young children. Most of the cases are associated with viral or bacterial infections. In some cases, AIHA can be characterized by a chronic course and an unsatisfactory control of hemolysis, thus requiring prolonged immunosuppressive therapy. Case report Especially in children younger...

Autoimmune hemolytic anemia (AIHA) is caused by hemolysis induced by the reaction of autoantibodies with red blood cells (RBCs) [1-4]. Events that lead to AIHA include extravascular hemolysis caused by phagocytosis of erythrocyte-bound IgG in the spleen (hemolytic mechanism), activation of polyclonal B cells, reactions induced by molecular mimicry of exogenous antigens, breakdown of immune tole...

1. Sensitization confers upon the red cell the property of adsorbing complement from solution. The submicroscopic film of immune serum protein deposited upon the cell surface during sensitization, and completely analogous to the precipitate formed in a soluble antigen-antibody reaction (e.g., sheep serum vs. rabbit anti-sheep serum) acts as absorbent, the degree of sensitization (size of the fi...

Introduction: Immune mediated hemolytic anemia (IMHA) is one of the most common immune mediated conditions in dogs treated in both the primary care and referral settings. Despite decades of knowledge and research on IMHA, it remains to be a frustrating and very deadly disease with reported mortality rates range from 22-70%. Although the highest mortality rates were seen in the earlier studies, ...

Six cases of immune hemolytic anemia attributed to donor-derived red cell antibodies after allogeneic bone marrow transplantation (BMT) are reported. In 2/6 cases, severe intravascular hemolysis was seen, 6/6 required increased red cell transfusion, and 1/6 was treated by plasma exchange. All recipients were receiving cyclosporine to prevent graft-v-host disease. Investigations showed that in e...

background autoimmune hemolytic anemia is a hematologic disorder that is rarely observed in infants and young children. most of the cases are associated with viral or bacterial infections. in some cases, aiha can be characterized by a chronic course and an unsatisfactory control of hemolysis, thus requiring prolonged immunosuppressive therapy. case report especially in children younger than 2 y...