Immune thrombocytopenia is an autoimmune disease with abnormal T cell immunity. Cytotoxic T cells, abnormal T regulatory cells, helper T cell imbalance, megakaryocyte maturation abnormalities and abnormal T cell anergy are involved in the pathogenesis of this condition. The loss of T cell-mediated immune tolerance to platelet auto-antigens plays a crucial role in immune thrombocytopenia. The in...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a variety of clinical manifestations related to viral tissue damage, as well virally induced immune response. Hyperstimulation the system can serve trigger for autoimmunity. Several immune-mediated have been described in course SARS-CoV-2 infection. Immune thrombocytopenic purpura (ITP) and autoimmune hemo...

Intravenous immunoglobulin (IVIG) is used to treat immune thrombocytopenia resulting from a variety of autoimmune and nonautoimmune diseases such as idiopathic thrombocytopenic purpura (ITP), heparin-induced thrombocytopenia, and posttransfusion purpura. IVIG is a limited resource and although considered safe, may nevertheless carry some risk of transferring disease. Its high cost makes monoclo...

Objectives: Immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disease characterized by thrombocytopenia. This review will examine the Notch-aromatic hydrocarbon receptor (AhR)-interleukin-22 (IL-22) signaling pathway regulatory mechanisms in ITP to generate ideas for pathogenesis and etiological investigation of disease. Mechanism: Studies had shown that abnormal imbalance immune...

Introduction: Many viral and bacterial infections result in thrombocytopenia are most common non-iatrogenic cause of thrombocytopenia. Infections can affect both platelet production survival. In addition, immune mechanisms also be a cause, as immune-mediated (ITP) children following infection. our setup, tropical like malaria, dengue leptospirosis formed the important causes Objectives: To corr...

OBJECTIVES The objective of this study was to compare hospitalisation duration, survival times, adverse events and cost of therapy in dogs with presumptive primary immune-mediated thrombocytopenia undergoing therapy with mycophenolate mofetil and corticosteroids versus cyclosporine and corticosteroids. METHODS A retrospective study of medical case records of dogs with presumed primary immune-...