introduction: glycoconjugates are a class of glycoproteins or glycolipids, their terminal sugars are responsible for cell-cell and/or cell-extracellular matrix interactions. aberrant glycosylation of these compounds are one of the most important aspects of cellular transformation, metastasis and escape of tumoral cells from immune system and resistance to antineoplastic drugs. recent studies sh...

BACKGROUND Colorectal cancer (CRC) is one of the most commonly diagnosed cancers worldwide. It is also known as the second leading cause of deaths as the early stage detection is not yet available by current methods. So identification of biomarkers can also be functional in early diagnosis and prognosis. MATERIALS AND METHODS We examined sera from 60 CRC patients of different stages as a sour...

Cell-mediated immunity has been investigated using the leucocyte migration test in 32 patients with chronic active hepatitis or primary biliary cirrhosis. Twenty-six (75%) showed reactivity to liver extract. At least two antigens are involved. Cell-mediated reactivity was confirmed in some cases using lymphocyte ;blast' transformation. There was no correlation with the presence of auto-antibodi...

It was recently proposed that T lymphocytes, which closely interact with APCs, can extract surface molecules from the presenting cells when they dissociate. These observations question the classical view of discrete interactions between phenotypically defined cell populations. In this review, we summarize some reports suggesting that membrane exchange at the immune synapse can be a vector for i...

per hour elevates serum ascorbate from about 1 mg/dl to a maximum of 4 mg/dl. Again, the physiological significance of Lewin's observation is questionable. After stress or ACTH secretion, adrenocorticosteroid secretion is associated with decreased adrenal cholesterol and ascorbate. From this finding, Lewin hypothesizes that vitamin C plays an important role in the synthesis of adrenal steroids....

Visna virus inoculation of mice before immunization with unrelated antigens caused suppression of humoral and cell-mediated immune responses. The immunosuppressive effect was dependent on the virus dose and time of administration. The number of "background" antibody-producing spleen cells increased slightly after inoculation of Visna virus. Heat treatment of Visna virus abolished its immunosupp...

Objective(s) The aim of this study was to evaluate the expressions of two angiogenic immune-markers (CD-31 and VEGF), and one proliferative immune-marker (Ki-67) in oral pyogenic granulomas (PG), hemangiomas (Hem) and inflammatory gingivitis (IG). Materials and Methods Sixty cases of PG, Hem and IG (twenty cases each) were examined. Immunohistochemical (IHC) staining was performed based on r...

objective(s) the aim of this study was to evaluate the expressions of two angiogenic immune-markers (cd-31 and vegf), and one proliferative immune-marker (ki-67) in oral pyogenic granulomas (pg), hemangiomas (hem) and inflammatory gingivitis (ig). materials and methods sixty cases of pg, hem and ig (twenty cases each) were examined. immunohistochemical (ihc) staining was performed based on rout...

Regional draining lymph nodes (RDLN) from rabbits with herpes virus disciform keratitis (defined as corneal edema or corneal edema with concomitant epithelial lesions) were tested for general as well as specific immune cap-city. Although general RDLN immune capacity did not seem to be impaired, specific reactivity to herpes antigens was found only in those rabbits which presented with disciform...

PURPOSE Engineering T cells with receptors to redirect the immune system against cancer has most recently been described as a scientific breakthrough. However, a main challenge remains the GMP-grade purification of immune cells selectively expressing the introduced receptor in order to reduce potential side effects due to poorly or nonengineered cells. EXPERIMENTAL DESIGN In order to test a n...