Kimura's disease (KD) is a rare idiopathic condition of unknown etiology. The disease is characterized by swelling and lesions in the head and neck region, with involvement of the subcutaneous soft tissue, major salivary glands and lymph nodes. Patients almost always have eosinophilia and elevated serum immunoglobulin E levels. The diagnosis is established by biopsy. KD is usually self limiting...

this study was undertaken to assess vitamin c status in allergic children. twenty-six allergic patients and 46 apparently healthy controls aged 7-16 years of both sexes were introduced. all patients were diagnosed being allergic based on their histories, physical examinations and laboratory findings. blood samples were obtained between 09.00-11.00 to determine total serum immunoglobulin e, hist...

although migraine affects about 15 % of the population, and many studies have been performed to find the mechanism and successful management, the physiopathology of migraine is still largely unknown. the possibility of an ige-mediated allergic mechanism and the role of histamine remains controversial. the aim of the present study was the evaluation of serum total ige and histamine levels in mig...

introduction chicken is the only avian species in which polyclonal antibodies, like igg is transported from the hen to the egg yolk in a similar manner as the transport of mammalian igg from the mother to the fetus. immunoglobulin y in the chicken is transported to the egg and accumulates in the egg yolk in large quantities. igy is an egg yolk antibody that has been used widely for treatment an...

A 7 year-old male presented with recurrent fever, cough and respiratory distress for over last 2 years. Based on extremely high eosinophil count, high Immunoglobulin E, increase in eosinophilic precursors in bone marrow, and positive antigen test for Wuchereria bancrofti, a diagnosis of Tropical Pulmonary Eosinophilia with Eosinophilic Leukemoid Reaction was made. Complete recovery was achieved...

IgE antibodies to gal-α-1,3-gal-β-1,4-GlcNAc (α-gal) can mediate a novel form of delayed anaphylaxis to red meat. Although IgG antibodies to α-gal (anti-α-gal or anti-Gal) are widely expressed in humans, IgE anti-α-gal is not. We explored the relationship between the IgG and IgE responses to both α-gal and the related blood group B antigen. Contradicting previous reports, antibodies to α-gal we...

IgE antibodies with high affinity for their antigens can be stably cross-linked at low concentrations by trace amounts of antigen, whereas IgE antibodies with low affinity bind their antigens weakly. In this study, we find that there are two distinct pathways to generate high and low affinity IgE. High affinity IgE is generated through sequential class switching (μ→γ→ε) in which an intermediary...