The value as a thyroid function test of a new, rapid, and highly sensitive immunoradiometric assay for thyroid stimulating hormone (TSH) was assessed in 188 consecutive new patients with suspected hyperthyroidism. The diagnosis was made on clinical grounds and on the basis of serum total triiodothyronine and thyroxine concentrations and the response of TSH to thyrotrophin releasing hormone (TRH...

The dose/response curve in enzyme-multiplied immunoassays (EMIT) and related techniques may be described by the same "four-parameter logistic function" as has proven useful in radioimmunoassays, immunoradiometric assays (IRMA), and two-site immunoradiometric ("sandwhich") assays. This function provides an empirical description of the dose/response curve by use of an objective least-squares regr...

this report describes the histological and immunohistochemical features of a small intestinal tumor that resembled a human gastrointestinal stromal tumor (gists) in a seven-year-old male cross-breed dog. this was unique because of the expression of desmin by the tumor. grossly, the white-gray tumor measured 8.0 × 4.0 × 6.5 cm and was 760 gram in weight. it was cystic and enveloped the jejunum. ...

Ferritin is the major intracellular iron storage protein found in the body, consisting of a spherical protein shell of MW 450 000 made up of 24 identical subunits. Iron is stored in the inner core as crystalline ferric-oxide-phosphate. Ferritin is found mainly in the reticuloendothelial system, predominantly in the spleen, liver, and bone marrow. Circulating levels of ferritin have been shown t...

CA 125 is an antigenic determinant expressed by greater than 80% of nonmucinous epithelial ovarian carcinomas. An immunoradiometric assay has been developed using a murine mono clonal antibody (OC125) to quantitate CA 125 in human serum. This immunoradiometric assay was optimized for specificity, sensitivity, and performance characteristics. Using a simultane ous immunoradiometric assay, the me...