The pharmaceutical industry is facing enormous challenges due to high drug attribution rates. For the past decades, novel methods have been developed for safety and efficacy testing, as well as for improving early development stages. In vitro screening methods for drug-receptor binding are considered to be good alternatives for decreasing costs in the identification of drug candidates. However,...

We present a novel study on label-free recognition and distinction of drug resistant breast cancer cells (MCF-7 DOX) from their parental cells (MCF-7 WT) via impedimetric measurements. Drug resistant cells exhibited significant differences in their dielectric properties compared to wild-type cells, exerting much higher extracellular resistance (Rextra ). Immunostaining revealed that MCF-7 DOX c...

A biosensing platform based on the principle of real-time unlabeled impedimetric detection has been developed. The platform detects bio-targets by measuring impedance changes in real-time. This biosensor is aimed at multiple segments of the life sciences market and is planned for commercialization in the near future. These products will leverage monolithic integration concepts, unique device te...

The suitability of polysilicon as a material for the fabrication of interdigitated electrodes and their application to the development of sensors is studied in this work. The main interest in using this material lies in the possibility of obtaining integrated sensors with commercial CMOS technologies and simple post-processing steps. Electrodes with 3μm finger width and 3, 10, and 20μm spacing ...

This paper presents a fully integrated nano interdigitated electrodes array (nIDA) and microfluidic system on polymer substrate. It can be sed as a miniaturized, sensitive, and easy-to-use impedimetric sensor for genomics, proteomics, and cellular analysis. The benefits gained from nanoscale IDA is very high sensitivity for monitoring protein binding behavior. With the intention of integrating ...

A portable low-cost microcontroller based testing system was designed and constructed to detect phthalates in aqueous media. Phthalates, especially di (2-ethylhexyl) phthalate is the most ubiquitous endocrine disrupting compound (EDC) posing highest reproductive toxicity threat to all living species on earth. Frequency response analyser (FRA) approach was used to develop the rapid response, non...

By integrating chemical reactions on a large-scale integration (LSI) chip, new types of device can be created. For biomedical applications, monolithically integrated sensor arrays for potentiometric, amperometric and impedimetric sensing of biomolecules have been developed. The potentiometric sensor array detects pH and redox reaction as a statistical distribution of fluctuations in time and sp...