Aluminium salts are the most common adjuvants in infant vaccines. The aluminium content of a vaccine is provided by manufacturer and indicated on patient information leaflet. There no independent verification, for example European Medicines Agency, We have measured thirteen vaccines using microwave-assisted acid peroxide digestion followed transversely heated graphite furnace atomic absorption ...

Phenotypic differences in analgesic sensitivity to codeine (3-methoxymorphine) results from polymorphisms in cytochrome P450-2D6, which catalyzes O-demethylation of codeine to morphine. However, O-demethylation reportedly is not required for analgesic activity of the 7,8-saturated codeine congeners dihydrocodeine, hydrocodone, and oxycodone. This study determined the potency and efficacy of the...

BACKGROUND Poor and uninsured people have increased risk of medical and psychiatric illness, but they might be more reluctant to seek care than those with higher incomes. Little information exists about the biopsychosocial problems and concerns of this population in primary care. METHODS We surveyed 500 consecutive patients (aged 18 to 64 years) in a primary care clinic serving only uninsured...

Statistical and biochemical studies have revealed nonrandom patterns in codon assignments. The canonical genetic code is known to be highly efficient in minimizing the effects of mistranslational errors and point mutations, since it is known that, when an amino acid is converted to another due to error, the biochemical properties of the resulted amino acid are usually very similar to those of t...