AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or ce...

OBJECTIVES We explored long-term health consequences of age at sexual initiation and of abstinence until marriage to evaluate empirical support for the claim that postponing sexual initiation has beneficial health effects. METHODS We analyzed data from the 1996 National Sexual Health Survey, a cross-sectional study of the US adult population. We compared sexual health outcomes among individua...

hypohidrotic ectodermal dysplasia (hed) is a rare congenital disorder arising from deficient development of ectoderm-derived structures including skin, nails, glands and teeth. the phenotype of hed is associated with mutation in eda, edar, edaradd and nemo genes, all of them disruptingnf-κb signaling cascade necessary for initiation, formation and differentiation in the embryo and adult. here w...

in order to prevent of inflorescence bud abscission and reduce of alternate bearing in pistachio cv. ‘ohadi’ an experiment with 12 treatments including of girdling, fruit thinning, application of urea (0.5%), sucrose (3 and 5%) and their combination with urea, zinc sulfate (0.05 and 0.1% of pure zinc) and also their combination with urea in 3 replication and during 2 stages, was conducted in 20...

OBJECTIVES The primary aim of the study was to gain insight into the relative risk of clinically relevant oral candidiasis following inhaled corticosteroid (ICS) initiation over time. A secondary aim was to analyse the influence of patient characteristics and co-medication on the occurrence of this adverse effect. METHODS Drug prescription data from 1994 to 2011 were retrieved from the IADB.n...

embryogenic callus initiation from anther and whole flower explants in four grapevine cultivars including flame seedless, shahroodi, perlette and red sultanina cultured on piv and harst nutrient media was studied. results showed that whole flower explants of ‘flame seedless’ cultured on piv medium had the most potential for callus production. later callus were transferred onto ges1ca medium for...

Phenotypic differences in analgesic sensitivity to codeine (3-methoxymorphine) results from polymorphisms in cytochrome P450-2D6, which catalyzes O-demethylation of codeine to morphine. However, O-demethylation reportedly is not required for analgesic activity of the 7,8-saturated codeine congeners dihydrocodeine, hydrocodone, and oxycodone. This study determined the potency and efficacy of the...