Titanium alloy Ti–6Al–4V and nickel-based superalloy Inconel 718 have been widely employed in modern manufacturing. The published literature on high speed machining (HSM) of the two materials often involves different machining set-up, which makes it difficult to directly apply the research findings from onematerial to the other to select the most appropriate tool geometry and cutting conditions...

Laser direct metal deposition (LDMD) has developed from a prototyping to a single metal manufacturing tool. Its potential for creating multimaterial and functionally graded structures is now beginning to be explored. This work is a first part of a study in which a single layer of Inconel 718 is deposited on Ti-6Al-4V substrate. Single layer tracks were built at a range of powder mass flow rates...

Johnson–Cook (J-C) material model is often used for Finite Element (FE) modeling of cutting processes and it affects significantly the results of simulation. Since experimentally determination of J-C equation parameters is an expensive and time-consuming task, in this paper, a new and efficient methodology was implemented based on the evolutionary optimization algorithm to identify new J-C mate...

The pharmacological profile of BR-A-657, 2-n-butyl-5-dimethylamino-thiocarbonyl-methyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}-pyrimidin-4(3H)-one, a new nonpeptide AT1-selective angiotensin receptor antagonist, has been investigated in a variety of in vitro and in vivo experimental models. In the present study, BR-A-657 displaced [(125)I][Sar(1)-Ile(8)]angiotensin II (Ang II) f...

Article history: Received 2 January 2015 Received in revised form 22 October 2015 Accepted 23 October 2015 Available online 27 October 2015 The hot deformation behaviour of Inconel alloy IN718 was studied in the temperature range of 950–1100 °C and at strain rates of 0.01 and 1 s with a view to understand the microstructural evolution as a function of strain rate and temperature. For this purpo...

Abstract The thermal analysis is performed on a heated Inconel 617 honeycomb-core sandwich panel. Sandwich panel is supported at its four edges with spar-like sub-structures that acted as heat sinks, which are generally not considered in the classical analysis. One side of the panel is subjected to a heat flux on the surface. Two types of surface heating were considered: (1) hexagonal honeycomb...

INTRODUCTION The NBN gene product is part of the MRE11/RAD50/NBN complex, which plays an essential role in genomic stability. In the study we try to answer the question what is the effect of irradiation on DNA synthesis, NBN gene expression and chromosomal stability in cells with homozygous c.657-661del, and heterozygous c.657-661del, p.I171V and p.R215W NBN gene mutations. MATERIAL AND METHO...

ABSTRACT Inconel 718 is a difficult-to-cut nickel-based superalloy commonly used in aerospace industry. This paper presents an experimental study of the tool wear propagation and cutting force variations in the end milling of Inconel 718 with coated carbide inserts. The experimental results showed that significant flank wear was the predominant failure mode affecting the tool life. The tool fla...

The damage accumulation behavior of different grain boundary structures in Inconel 690 (Ni-29wt%Cr-9wt%Fe) was investigated in the presence of large, localized plastic strains induced by nanoindentation. Spatially-resolved hardness was measured as a function of lateral distance from ‘random’ high-angle grain boundaries and twin boundaries. The confinement of induced defects between the indenter...

The effects of cutting tool coating material and cutting speed on cutting forces and surface roughness were investigated by Taguchi experimental design. Main cutting force, Fz is considered as a criterion. The effects of machining parameters were investigated using Taguchi L18 orthogonal array. Optimal cutting conditions were determined using the signal-to-noise (S/N) ratio which is calculated ...