OBJECTIVE Type 2 diabetes and obesity have genetic and environmental determinants. We studied the effects of different environments on these diseases in Pima Indians in Mexico and the U.S. RESEARCH DESIGN AND METHODS Adult Pima-Indian and non-Pima populations in the Sierra Madre mountains of Mexico were examined using oral glucose tolerance tests and assessments for obesity, physical activity...

PURPOSE OF REVIEW The purpose of this study was to review the epidemiology and pathogenesis of diabetes in Asian Indians with a particular focus on 'Asian Indian type 2 diabetes phenotype'. RECENT FINDINGS The prevalence of diabetes is rapidly increasing among Asian Indians, particularly in the past two decades. The diabetes rates in urban India now exceed that seen in Indians migrated to dev...

Pernicious anemia (PA), previously considered rare among American Indians, was diagnosed in 18 Indians during a 16-yr period at the Phoenix Indian Medical Center. These patients, from ten different tribes, did not vary significantly from all adult hospital admissions in proportionate sex, tribe, or blood group distribution. The current minimum prevalence of PA for southwestern Indians is 1:514 ...

OBJECTIVE To compare American-Indian and Caucasian mortality rates from diabetes among tribal Contract Health Service Delivery Areas (CHSDAs) in the Great Plains Region (GPR) and describe the disparities observed. RESEARCH DESIGN AND METHODS Mortality data from the National Center for Vital Statistics and Seer*STAT were used to identify diabetes as the underlying cause of death for each deced...

BACKGROUND American Indians in Oklahoma have higher rates of tobacco use (29.2%) than any other racial group in the state. The Oklahoma Tobacco Helpline provides free cessation services to all Oklahomans and implements strategies specifically aimed at increasing the utilization and effectiveness of cessation services for American Indians. PURPOSE To explore Helpline utilization patterns as we...

BACKGROUND CYP2C9 is one of the major drug metabolizing enzymes for many drugs including warfarin, NSAIDs and losartan. It is polymorphic in many populations. Data on the distribution of CYP2C9 and the implication of CYP2C9 polymorphism in the Malaysian population is lacking. Our objectives were therefore to investigate the prevalence of CYP2C9 variants among unrelated healthy volunteers of Mal...

The Seminole Indians of Florida were studied on thek three reservations for blood types, red cell enzymes, serum proteins, physical measurements, and relationships. Both serologic and morphologic factors suggest their close similarity to other Indians and small amount of admixture. The Florida Seminoles are similar to Cherokee “full-bloods” in their absence of Rho and their incidence of 0 and M...

Background: Individuals from South Asia have high diabetes prevalence despite low body weight. We compared the prevalence of diabetes among South Asian Indians with other U.S. ethnic groups and explored correlates of diabetes. Methods: This was a cross-sectional study of 150 South Asian Indians (ages 45–79) in California, using similar methods to the Multi-Ethnic Study of Atherosclerosis (MESA)...

Differences in tribal culture, history and settlement may explain why Indians in eastern Oklahoma have lower rates of alcohol-related arrests and deaths than do Indians in the western part of the state.